Apoc3 MGI Mouse Gene Detail - MGI:88055

Symbol

Apoc3
Name

apolipoprotein C-III

Feature Type

protein coding gene
IDs

MGI:88055
NCBI Gene: 11814
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr9:46144348-46146934 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 25.36 cM
Mapping Data

5 experiments

SNPs within 2kb

168 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88055	protein coding gene	Chr9:46144231-46146934 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034749	protein coding gene	Chr9:44863037-44867006 (-)
A/J	MGP_AJ_G0034730	protein coding gene	Chr9:43578727-43581485 (-)
AKR/J	MGP_AKRJ_G0034657	protein coding gene	Chr9:44466896-44469627 (-)
BALB/cJ	MGP_BALBcJ_G0034721	protein coding gene	Chr9:43300238-43302908 (-)
C3H/HeJ	MGP_C3HHeJ_G0034432	protein coding gene	Chr9:44940961-44943631 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035242	protein coding gene	Chr9:46143798-46146471 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032156	protein coding gene	Chr9:43109265-43111941 (-)
CAST/EiJ	MGP_CASTEiJ_G0033754	protein coding gene	Chr9:44799050-44803658 (-)
CBA/J	MGP_CBAJ_G0034404	protein coding gene	Chr9:47829041-47831728 (-)
DBA/2J	MGP_DBA2J_G0034563	protein coding gene	Chr9:43450011-43452720 (-)
FVB/NJ	MGP_FVBNJ_G0034504	protein coding gene	Chr9:42713766-42716438 (-)
LP/J	MGP_LPJ_G0034644	protein coding gene	Chr9:45181558-45184229 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034548	protein coding gene	Chr9:49577709-49580397 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035263	protein coding gene	Chr9:44386016-44388720 (-)
PWK/PhJ	MGP_PWKPhJ_G0033459	protein coding gene	Chr9:43369005-43371757 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033295	protein coding gene	Chr9:44714638-44717327 (-)
WSB/EiJ	MGP_WSBEiJ_G0033867	protein coding gene	Chr9:44435012-44437693 (-)

Human Ortholog

APOC3, apolipoprotein C3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APOC3, apolipoprotein C3
Synonyms

Apo-C3, ApoC-3, APOCIII
Links

HGNC:610

NCBI Gene ID: 345

UniProt: P02656
Chr Location

11q23.3; chr11:116829706-116833072 (+) GRCh38

MGI Vertebrate Homology

Apoc3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: APOC3
Gene Tree

Apoc3

Diseases

9 with human APOC3 associations

				Human Disease	Mouse Models
				apolipoprotein C-III deficiency IDs apolipoprotein C-III deficiency DOID:0111370 MESH:C566270 OMIM:614028
				chronic kidney disease IDs chronic kidney disease DOID:784 ICD10CM:N18.9 ICD9CM:585 ICD9CM:585.6 MESH:D007676 NCI:C9438 UMLS_CUI:C0022661
				cognitive disorder IDs cognitive disorder DOID:1561 ICD10CM:F09 MESH:D019965 NCI:C34870 UMLS_CUI:C0029227
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				familial combined hyperlipidemia IDs familial combined hyperlipidemia DOID:13809 ICD10CM:E78.49 MESH:D006950 NCI:C35637 OMIM:144250 UMLS_CUI:C0020474
				glucose intolerance IDs glucose intolerance DOID:10603 ICD10CM:R73.03 MESH:D018149 NCI:C34646 UMLS_CUI:C0271650
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				hyperlipoproteinemia type III IDs hyperlipoproteinemia type III DOID:3145 MESH:D006952 NCI:C34710 OMIM:617347 UMLS_CUI:C0020479
				type 1 diabetes mellitus IDs type 1 diabetes mellitus DOID:9744 ICD10CM:E10 KEGG:04940 MESH:D003922 NCI:C2986 OMIM:222100 UMLS_CUI:C0011854

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

16 phenotypes from 1 allele in 3 genetic backgrounds
1 phenotype from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

5
Gene trapped

1
Targeted

6
Transgenic

1
Genomic Mutations

1 involving Apoc3
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit reduced fasted triglyceride levels, increased triglyceride secretion rate, and loss of postprandial and obesity-associated hypertriglyceridemia.

less

All GO Annotations

65
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

150
Literature Summary

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

47
RefSeq

8
UniProt

4
CCDS

CCDS23141.1, CCDS80989.1

Ensembl

ENSMUSG00000032081 (Evidence)
NCBI Gene

11814

			Length	Strain/Species	Flank
genomic	11814	NCBI Gene Model \| MGI Sequence Detail	2587	C57BL/6J	± kb
transcript	NM_001289755	RefSeq \| MGI Sequence Detail	631	C57BL/6
polypeptide	P33622	UniProt \| EBI \| MGI Sequence Detail	99	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000004152 apolipoprotein C-III

(term hierarchy)
InterPro Domains

IPR008403 Apolipoprotein CIII

IPR038195 Apolipoprotein CIII superfamily
GlyGen

P33622 1 site

less

All nucleic 153

Genomic 3

cDNA 150

Microarray probesets 2

less

MGD-MRK-1371, MGD-MRK-1374

Summaries

All 74

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 26
Earliest

J:6686 Kratochvilova J, Dominant cataract mutations detected in offspring of gamma-irradiated male mice. J Hered. 1981 Sep-Oct;72(5):302-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Apoc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr89341	Chr9:46148701-46148706 (-)	-1,770 bp
Tssr89340	Chr9:46147054-46147087 (-)	-137 bp
Tssr89339	Chr9:46146980-46146991 (-)	-52 bp
Tssr89338	Chr9:46146929-46146963 (-)	-12 bp
Tssr89337	Chr9:46146587-46146604 (-)	338 bp
Tssr89336	Chr9:46145985-46146041 (-)	921 bp
Tssr89335	Chr9:46145812-46145831 (-)	1,112 bp
Tssr89334	Chr9:46145771-46145776 (-)	1,160 bp
Tssr89333	Chr9:46145750-46145769 (-)	1,174 bp
Tssr89332	Chr9:46144622-46144649 (-)	2,298 bp
Tssr89331	Chr9:46144547-46144576 (-)	2,372 bp
Tssr89330	Chr9:46144514-46144530 (-)	2,412 bp
Tssr89329	Chr9:46144468-46144501 (-)	2,449 bp
Tssr89328	Chr9:46144397-46144421 (-)	2,525 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24