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Apoc2 Gene Detail
Summary
  • Symbol
    Apoc2
  • Name
    apolipoprotein C2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88054
    NCBI Gene: 11813
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19405504-19411866 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.94 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    293 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88054
 protein coding gene Chr7:19405504-19411866 (-)
129S1/SvImJ ENSMUSG00200040622
 protein coding gene Chr7:12602827-12608906 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ ENSMUSG00180052773
 protein coding gene Chr7:12899177-12905539 (-)
C3H/HeJ ENSMUSG00175052162
 protein coding gene Chr7:13485364-13491447 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0029302
 protein coding gene Chr7:18971125-18981262 (-)
CAST/EiJ ENSTCUG00005047667
 protein coding gene Chr7:13507698-13513827 (-)
CBA/J ENSMUSG00210052509
 protein coding gene Chr7:12711907-12717984 (-)
DBA/2J ENSMUSG00185052109
 protein coding gene Chr7:16155456-16161854 (-)
FVB/NJ no annotation
JF1/MsJ ENSUMUG00000021911
 protein coding gene Chr7:19470343-19475637 (-)
LP/J ENSMUSG00230052104
 protein coding gene Chr7:20444536-20450613 (-)
NOD/ShiLtJ ENSMUSG00190028872
 protein coding gene Chr7:9368229-9374306 (-)
NZO/HlLtJ no annotation
PWK/PhJ ENSLUMG00010040537
 protein coding gene Chr7:2326017-2332228 (-)
SPRET/EiJ ENSMSPG00010050377
 protein coding gene Chr7:12445788-12450022 (-)
WSB/EiJ ENSIUOG00005053289
 protein coding gene Chr7:19163033-19169431 (+)



Homology
more
  • Human Ortholog
    APOC2, apolipoprotein C2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOC2, apolipoprotein C2
  • Synonyms
    APO-CII, APOC-II
  • Links
    NCBI Gene ID: 344
    UniProt: P02655

  • Chr Location
    19q13.32; chr19:44945709-44949580 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human APOC2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an endonuclease-mediated allele exhibit increased circulating triglyceride, decreased circulating HDL cholesterol, and abnormal lipoprotein levels. Mice heterozygous for the allele exhibit an intermediate phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    61
  • cDNA Data
    97
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11813 NCBI Gene Model | MGI Sequence Detail 6363 C57BL/6J ±  kb
    transcript NM_001277944 RefSeq | MGI Sequence Detail 727 ZRU/MplStud  
    polypeptide Q05020 UniProt | EBI | MGI Sequence Detail 97 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 114
      Genomic 1
      cDNA 103
      Primer pair 8
      Other 2
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1373
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 17
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
    • Latest
      J:347607 Benzow K, et al., Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice. Alzheimers Dement. 2024 Apr;20(4):3080-3087
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory