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Chrna2 Gene Detail
Summary
  • Symbol
    Chrna2
  • Name
    cholinergic receptor nicotinic alpha 2 subunit
  • Synonyms
    Acra-2, Acra2, MGC:18795
  • Feature Type
    protein coding gene
  • IDs
    MGI:87886
    NCBI Gene: 110902
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:66372488-66390397 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    543 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87886
 protein coding gene Chr14:66370685-66390397 (+)
129S1/SvImJ ENSMUSG00200029569
 protein coding gene Chr14:54973003-54990904 (+)
A/J ENSMUSG00195013013
 protein coding gene Chr14:55150322-55168234 (+)
AKR/J ENSMUSG00220026723
 protein coding gene Chr14:54490840-54508756 (+)
BALB/cJ ENSMUSG00180033652
 protein coding gene Chr14:54766539-54784456 (+)
C3H/HeJ ENSMUSG00175030360
 protein coding gene Chr14:56509424-56527323 (+)
C57BL/6NJ ENSMUSG00215013365
 protein coding gene Chr14:54705480-54723389 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019436
 protein coding gene Chr14:57289485-57309135 (+)
CAST/EiJ ENSTCUG00005038217
 protein coding gene Chr14:56409463-56427384 (+)
CBA/J ENSMUSG00210036427
 protein coding gene Chr14:55137675-55155592 (+)
DBA/2J ENSMUSG00185031774
 protein coding gene Chr14:60307244-60325145 (+)
FVB/NJ ENSMUSG00205028903
 protein coding gene Chr14:54653169-54671087 (+)
JF1/MsJ ENSUMUG00000034332
 protein coding gene Chr14:71481062-71498958 (+)
LP/J ENSMUSG00230036706
 protein coding gene Chr14:72336522-72354423 (+)
NOD/ShiLtJ ENSMUSG00190036890
 protein coding gene Chr14:54932390-54950306 (+)
NZO/HlLtJ ENSMUSG00225038644
 protein coding gene Chr14:62665262-62683182 (+)
PWK/PhJ ENSLUMG00010033689
 protein coding gene Chr14:54371598-54389515 (+)
SPRET/EiJ ENSMSPG00010028882
 protein coding gene Chr14:57861432-57878562 (+)
WSB/EiJ ENSIUOG00005039667
 protein coding gene Chr14:54368956-54386873 (+)



Homology
more
  • Human Ortholog
    CHRNA2, cholinergic receptor nicotinic alpha 2 subunit
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRNA2, cholinergic receptor nicotinic alpha 2 subunit
  • Links
    NCBI Gene ID: 1135
    UniProt: Q15822

  • Chr Location
    8p21.2; chr8:27459756-27479883 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CHRNA2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 4 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls. Homozygosity for KO or the p.L282S mutation affects synaptic transmission and long term potentiation and leads to impaired contextual fear conditioning behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    133
  • cDNA Data
    4
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022041 Ensembl Gene Model | MGI Sequence Detail 17910 C57BL/6J ±  kb
    transcript ENSMUST00000206455 Ensembl | MGI Sequence Detail 1933 Not Applicable  
    polypeptide ENSMUSP00000145896 Ensembl | MGI Sequence Detail 512 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005455 neuronal acetylcholine receptor subunit alpha-2
      (term hierarchy)
    • InterPro Domains
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    • GlyGen
      Q91X60 3 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 6
      Primer pair 2
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1055, MGD-MRK-1059, MGI:2384825
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 10
      Gene Ontology 11
      Phenotypes 24
    • Earliest
      J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
    • Latest
      J:374720 Zhu K, et al., Chrna2-driven CRE Is Expressed in Beige Adipocytes. Endocrinology. 2024 Nov 26;166(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory