Chrna2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chrna2
cholinergic receptor nicotinic alpha 2 subunit
MGI:87886

18 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chrna2^em1(IMPC)Mbp/Chrna2^em1(IMPC)Mbp C57BL/6NCrl-Chrna2^em1(IMPC)Mbp/MbpMmucd	abnormal caudal vertebrae morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal skin morphology	J:211773
	small kidney	J:211773
	thick skin	J:211773
Chrna2^tm1.1Slot/Chrna2^tm1.1Slot involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J	normal behavior/neurological phenotype	J:272596
	normal embryo phenotype	J:272596
	enhanced long-term potentiation	J:272596
	normal growth/size/body region phenotype	J:272596
	impaired contextual conditioning behavior	J:272596
	increased locomotor activity	J:272596
	increased vertical activity	J:272596
	normal nervous system phenotype	J:272596
Chrna2^tm1Dgen/Chrna2^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:101679
Chrna2^tm1Jbou/Chrna2^tm1Jbou B6.129X1-Chrna2^tm1Jbou	abnormal excitatory postsynaptic currents	J:126075
	abnormal inhibitory postsynaptic currents	J:126075
	abnormal long-term potentiation	J:126075
	normal behavior/neurological phenotype	J:272596
	decreased physiological sensitivity to xenobiotic	J:126075
	normal embryo phenotype	J:272596
	normal growth/size/body region phenotype	J:272596
	impaired contextual conditioning behavior	J:272596
	increased locomotor activity	J:272596
	normal nervous system phenotype	J:126075

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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