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Gene Expression Data
Assay Details
Assay
Reference: J:284490 Varum S, et al., Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Cell Stem Cell. 2019 Apr 4;24(4):637-653.e9
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7332913
Gene symbol: Sox10
Gene name: SRY (sex determining region Y)-box 10
Antibody: anti-Sox10 (N-20, sc-17342)
Detection system: Secondary antibody
Results
Specimen S1B Control: embryonic day 9.5; Yy1tm2Yshi/Yy1+ (more )
Note: Control could be Yy1fl/+; Yy1fl/fl or Yy1fl/+;Wnt1-Cre. Double labeled: red - Sox10; green - Yy1 (assay MGI:7332911).
Structure Cell Type Level Pattern Image Note
TS15: migrating neural crest migratory trunk neural crest cell Present S1B Control
Specimen S1B Yy1 cko: embryonic day 9.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Yy1tm2Yshi/Yy1tm2Yshi (more )
Note: Conditional mutant. Double labeled: red - Sox10; green - Yy1 (assay MGI:7332911).
Structure Cell Type Level Pattern Image Note
TS15: migrating neural crest migratory trunk neural crest cell Present S1B Yy1 cko
Specimen 1H Sox10 Control: embryonic day 11.5; Yy1tm2Yshi/Yy1+ (more )
Note: Control could be Yy1fl/+; Yy1fl/fl or Yy1fl/+;Wnt1-Cre.
Structure Cell Type Level Pattern Image Note
TS19: 1st branchial arch neural crest cell Present 1H Sox10 Control
Specimen 1H Sox10 Yy1 cko: embryonic day 11.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Yy1tm2Yshi/Yy1tm2Yshi (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS19: 1st branchial arch neural crest cell Present 1H Sox10 Yy1 cko Expression unaltered compared to control.
Specimen S1G Control: embryonic day 11.5; Yy1tm2Yshi/Yy1+ (more )
Note: Control could be Yy1fl/+; Yy1fl/fl or Yy1fl/+;Wnt1-Cre. Double labeled: red - Sox10; green - Nefm (assay MGI:7332915).
Structure Level Pattern Image Note
TS19: dorsal root ganglion Present S1G Control
Specimen S1G Yy1 cko: embryonic day 11.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Yy1tm2Yshi/Yy1tm2Yshi (more )
Note: Conditional mutant. Double labeled: red - Sox10; green - Nefm (assay MGI:7332915).
Structure Level Pattern Image Note
TS19: dorsal root ganglion Weak S1G Yy1 cko Expression moderately reduced at E11.5
Specimen 1O Control: embryonic day 13.5; Yy1tm2Yshi/Yy1+ (more )
Note: Control could be Yy1fl/+; Yy1fl/fl or Yy1fl/+;Wnt1-Cre. Double labeled: red - Sox10; green - Nefm (assay MGI:7332915).
Structure Level Pattern Image Note
TS21: dorsal root ganglion Present 1O Control
Specimen 1O Yy1 cko: embryonic day 13.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Yy1tm2Yshi/Yy1tm2Yshi (more )
Note: Conditional mutant. Double labeled: red - Sox10; green - Nefm (assay MGI:7332915).
Structure Level Pattern Image Note
TS21: dorsal root ganglion Present 1O Yy1 cko Normal differentiation of DRG cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory