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Angptl8 Gene Detail
Summary
  • Symbol
    Angptl8
  • Name
    angiopoietin-like 8
  • Synonyms
    Gm6484, Lipasin, Rifl
  • Feature Type
    protein coding gene
  • IDs
    MGI:3643534
    NCBI Gene: 624219
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21746806-21748643 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3643534
 protein coding gene Chr9:21746806-21748643 (+)
129S1/SvImJ ENSMUSG00200046601
 protein coding gene Chr9:18701058-18702893 (+)
A/J ENSMUSG00195031946
 protein coding gene Chr9:18537682-18539519 (+)
AKR/J ENSMUSG00220031055
 protein coding gene Chr9:18540116-18541953 (+)
BALB/cJ ENSMUSG00180036728
 protein coding gene Chr9:18671978-18673815 (+)
C3H/HeJ ENSMUSG00175042068
 protein coding gene Chr9:18634515-18636352 (+)
C57BL/6NJ ENSMUSG00215035542
 protein coding gene Chr9:18631814-18633651 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031884
 protein coding gene Chr9:17842391-17844202 (+)
CAST/EiJ ENSTCUG00005030266
 protein coding gene Chr9:18683624-18685452 (+)
CBA/J ENSMUSG00210033400
 protein coding gene Chr9:18615450-18617287 (+)
DBA/2J ENSMUSG00185026169
 protein coding gene Chr9:18730750-18732587 (+)
FVB/NJ ENSMUSG00205041909
 protein coding gene Chr9:18959467-18961308 (+)
JF1/MsJ ENSUMUG00000042187
 protein coding gene Chr9:18837501-18839357 (+)
LP/J ENSMUSG00230041564
 protein coding gene Chr9:19118689-19120530 (+)
NOD/ShiLtJ ENSMUSG00190028212
 protein coding gene Chr9:18652451-18654292 (+)
NZO/HlLtJ ENSMUSG00225048860
 protein coding gene Chr9:19072723-19074560 (+)
PWK/PhJ ENSLUMG00010041440
 protein coding gene Chr9:18728446-18730348 (+)
SPRET/EiJ ENSMSPG00010022120
 protein coding gene Chr9:18958420-18960249 (+)
WSB/EiJ ENSIUOG00005043916
 protein coding gene Chr9:18201322-18203163 (+)



Homology
more
  • Human Ortholog
    ANGPTL8, angiopoietin like 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANGPTL8, angiopoietin like 8
  • Synonyms
    C19orf80, PRO1185, PVPA599, RIFL, TD26
  • Links
    NCBI Gene ID: 55908
    UniProt: Q6UXH0

  • Chr Location
    19p13.2; chr19:11237502-11241943 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit markedly reduced serum triglyceride levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 624219 NCBI Gene Model | MGI Sequence Detail 1838 C57BL/6J ±  kb
    transcript NM_001080940 RefSeq | MGI Sequence Detail 887 C57BL/6  
    polypeptide Q8R1L8 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 1
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 1
      Gene Ontology 13
      Phenotypes 25
    • Earliest
      J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
    • Latest
      J:386956 Wei J, et al., Liver-specific expression of ANGPTL8 promotes Alzheimer's disease progression through activating microglial pyroptosis. J Neuroinflammation. 2025 Jul 9;22(1):177
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory