Sequence Detail

ID/Version

Q8R1L8 (UniProt | EBI)

Last sequence update: 2008-02-26
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Angiopoietin-like protein 8 {ECO:0000312|MGI:MGI:3643534};AltName: Full=Betatrophin {ECO:0000303|PubMed:24043787};AltName: Full=Lipasin {ECO:0000303|PubMed:22809513};AltName: Full=Refeeding-induced fat and liver protein {ECO:0000303|PubMed:2

Provider

SWISS-PROT

Sequence

Polypeptide 198 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Angptl8	angiopoietin-like 8	22	96	3	8

Sequence references in MGI

J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
J:187261 Ren G, et al., Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am J Physiol Endocrinol Metab. 2012 Aug;303(3):E334-51
J:188548 Zhang R, Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochem Biophys Res Commun. 2012 Aug 10;424(4):786-92
J:192349 Quagliarini F, et al., Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19751-6
J:197679 Yi P, et al., Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell. 2013 May 9;153(4):747-58
J:217254 Jiao Y, et al., Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting. Diabetes. 2014 Apr;63(4):1283-8
J:217262 Wang Y, et al., Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16109-14
J:217383 Gusarova V, et al., ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell. 2014 Oct 23;159(3):691-6