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Mir221 Gene Detail
Summary
  • Symbol
    Mir221
  • Name
    microRNA 221
  • Synonyms
    mir 221, Mirn221, mmu-mir-221
Location &
Maps
more
  • Sequence Map
    ChrX:19012533-19012627 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 14.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3619066
 miRNA gene ChrX:19012533-19012627 (-)
129S1/SvImJ ENSMUSG00200015883
 miRNA gene ChrX:13777107-13777201 (-)
A/J ENSMUSG00195007575
 miRNA gene ChrX:13775090-13775184 (-)
AKR/J ENSMUSG00220018453
 miRNA gene ChrX:13315348-13315442 (-)
BALB/cJ ENSMUSG00180022950
 miRNA gene ChrX:13742761-13742855 (-)
C3H/HeJ ENSMUSG00175029592
 miRNA gene ChrX:13742924-13743018 (-)
C57BL/6NJ ENSMUSG00215018212
 miRNA gene ChrX:14393000-14393094 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0008316
 miRNA gene ChrX:12482161-12482255 (-)
CAST/EiJ ENSTCUG00005027840
 miRNA gene ChrX:13686720-13686814 (-)
CBA/J ENSMUSG00210020623
 miRNA gene ChrX:13806145-13806239 (-)
DBA/2J ENSMUSG00185032157
 miRNA gene ChrX:20406738-20406832 (-)
FVB/NJ ENSMUSG00205024690
 miRNA gene ChrX:13485525-13485619 (-)
JF1/MsJ ENSUMUG00000029760
 miRNA gene ChrX:34227619-34227713 (-)
LP/J ENSMUSG00230007030
 miRNA gene ChrX:24976166-24976260 (-)
NOD/ShiLtJ ENSMUSG00190028345
 miRNA gene ChrX:13769877-13769971 (-)
NZO/HlLtJ ENSMUSG00225033625
 miRNA gene ChrX:30210427-30210521 (-)
PWK/PhJ ENSLUMG00010016701
 miRNA gene ChrX:13626396-13626490 (-)
SPRET/EiJ ENSMSPG00010011095
 miRNA gene ChrX:14823621-14823715 (-)
WSB/EiJ ENSIUOG00005033892
 miRNA gene ChrX:10390033-10390127 (-)



Homology
more
  • Human Ortholog
    MIR221, microRNA 221
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR221, microRNA 221
  • Synonyms
    mir-221, MIRN221, miRNA221
  • Links
    NCBI Gene ID: 407006

  • Chr Location
    chrX:45746157-45746266 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human MIR221 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    624
  • Tissues
    22
  • Literature Summary
    6
Sequences &
Gene Models
less
  • All Sequences
    24
  • RefSeq
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 723827 NCBI Gene Model | MGI Sequence Detail 95 C57BL/6J ±  kb
transcript NR_029806 RefSeq | MGI Sequence Detail 95 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 5
    Primer pair 3
    Other 2
Other Database
Links
less
miRBase MI0000709
References
more
  • Summaries
    All 54
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 1
  • Earliest
    J:87295 Lim LP, et al., Vertebrate microRNA genes. Science. 2003 Mar 7;299(5612):1540
  • Latest
    J:354582 Roumelioti F, et al., Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components. Elife. 2024 Sep 5;13
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory