About   Help   FAQ
Kank4 Gene Detail
Summary
  • Symbol
    Kank4
  • Name
    KN motif and ankyrin repeat domains 4
  • Synonyms
    Ankrd38
  • Feature Type
    protein coding gene
  • IDs
    MGI:3043381
    NCBI Gene: 242553
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:98643135-98705774 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 45.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2194 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3043381
 protein coding gene Chr4:98643129-98706295 (-)
129S1/SvImJ ENSMUSG00200027302
 protein coding gene Chr4:93622564-93686304 (-)
A/J ENSMUSG00195008220
 protein coding gene Chr4:94152305-94216039 (-)
AKR/J ENSMUSG00220005814
 protein coding gene Chr4:93628765-93691417 (-)
BALB/cJ ENSMUSG00180029791
 protein coding gene Chr4:93097697-93161434 (-)
C3H/HeJ ENSMUSG00175012854
 protein coding gene Chr4:94059968-94123689 (-)
C57BL/6NJ ENSMUSG00215010576
 protein coding gene Chr4:94016738-94079385 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026186
 protein coding gene Chr4:90879997-90943090 (-)
CAST/EiJ ENSTCUG00005006859
 protein coding gene Chr4:93335065-93397744 (-)
CBA/J ENSMUSG00210027122
 protein coding gene Chr4:93625475-93689199 (-)
DBA/2J ENSMUSG00185021492
 protein coding gene Chr4:94413989-94477680 (-)
FVB/NJ ENSMUSG00205011891
 protein coding gene Chr4:92624604-92687256 (-)
JF1/MsJ ENSUMUG00000036967
 protein coding gene Chr4:94520200-94589855 (-)
LP/J ENSMUSG00230019656
 protein coding gene Chr4:97732126-97795858 (-)
NOD/ShiLtJ ENSMUSG00190024577
 protein coding gene Chr4:93095442-93159176 (-)
NZO/HlLtJ ENSMUSG00225032732
 protein coding gene Chr4:102865640-102928271 (-)
PWK/PhJ ENSLUMG00010017892
 protein coding gene Chr4:92233019-92296012 (-)
SPRET/EiJ ENSMSPG00010007621
 protein coding gene Chr4:94464228-94526516 (-)
WSB/EiJ ENSIUOG00005002854
 protein coding gene Chr4:93412292-93475428 (-)



Homology
more
  • Human Ortholog
    KANK4, KN motif and ankyrin repeat domains 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KANK4, KN motif and ankyrin repeat domains 4
  • Synonyms
    ANKRD38, dJ1078M7.1
  • Links
    NCBI Gene ID: 163782
    UniProt: Q5T7N3

  • Chr Location
    1p31.3; chr1:62236165-62319434 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show impaired arteriogenesis of the collateral artery due to decreased endothelial cell proliferation in response to ischemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    611
  • Tissues
    6
  • cDNA Data
    8
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035407 Ensembl Gene Model | MGI Sequence Detail 62640 C57BL/6J ±  kb
    transcript ENSMUST00000102790 Ensembl | MGI Sequence Detail 4795 Not Applicable  
    polypeptide ENSMUSP00000099851 Ensembl | MGI Sequence Detail 1016 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000029568 KN motif and ankyrin repeat domain-containing protein 4
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR021939 Kank N-terminal motif
      IPR047184 KN motif and ankyrin repeat domain-containing protein 1-4
    • GlyGen
      Q6P9J5 4 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:3034422
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:326312 Zhang C, et al., KANK4 Promotes Arteriogenesis by Potentiating VEGFR2 Signaling in a TALIN-1-Dependent Manner. Arterioscler Thromb Vasc Biol. 2022 Jun;42(6):772-788
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory