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Parp4 Gene Detail
Summary
  • Symbol
    Parp4
  • Name
    poly (ADP-ribose) polymerase family, member 4
  • Synonyms
    Adprtl1, C030027K23Rik, E230037B21Rik, p193, PH5P, VAULT3, VPARP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685589
    NCBI Gene: 328417
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56813076-56897251 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2165 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685589
 protein coding gene Chr14:56812982-56897256 (+)
129S1/SvImJ ENSMUSG00200039070
 protein coding gene Chr14:45397876-45482039 (+)
A/J ENSMUSG00195030341
 protein coding gene Chr14:45613093-45697267 (+)
AKR/J ENSMUSG00220027692
 protein coding gene Chr14:44939890-45024057 (+)
BALB/cJ ENSMUSG00180051313
 protein coding gene Chr14:45235134-45319299 (+)
C3H/HeJ ENSMUSG00175048563
 protein coding gene Chr14:46923881-47008042 (+)
C57BL/6NJ ENSMUSG00215048453
 protein coding gene Chr14:45131988-45216169 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019339
 protein coding gene Chr14:47815812-47902733 (+)
CAST/EiJ ENSTCUG00005044371
 protein coding gene Chr14:46904132-46995581 (+)
CBA/J ENSMUSG00210042005
 protein coding gene Chr14:45603583-45687748 (+)
DBA/2J ENSMUSG00185029860
 protein coding gene Chr14:50720076-50804324 (+)
FVB/NJ ENSMUSG00205039280
 protein coding gene Chr14:45007186-45091355 (+)
JF1/MsJ ENSUMUG00000041984
 protein coding gene Chr14:61880960-61965901 (+)
LP/J ENSMUSG00230052741
 protein coding gene Chr14:62766956-62851095 (+)
NOD/ShiLtJ ENSMUSG00190045260
 protein coding gene Chr14:45369908-45454070 (+)
NZO/HlLtJ ENSMUSG00225046236
 protein coding gene Chr14:53057300-53141708 (+)
PWK/PhJ ENSLUMG00010045541
 protein coding gene Chr14:44826977-44910974 (+)
SPRET/EiJ ENSMSPG00010041071
 protein coding gene Chr14:48324584-48407787 (+)
WSB/EiJ ENSIUOG00005041985
 protein coding gene Chr14:44785424-44869577 (+)



Homology
more
  • Human Ortholog
    PARP4, poly(ADP-ribose) polymerase family member 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PARP4, poly(ADP-ribose) polymerase family member 4
  • Synonyms
    ADPRTL1, ARTD4, p193, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C
  • Links
    NCBI Gene ID: 143
    UniProt: Q9UKK3

  • Chr Location
    13q12.12; chr13:24420931-24512925 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are helathy and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    608
  • Tissues
    8
  • cDNA Data
    23
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054509 Ensembl Gene Model | MGI Sequence Detail 84176 C57BL/6J ±  kb
    transcript ENSMUST00000161553 Ensembl | MGI Sequence Detail 6387 Not Applicable  
    polypeptide ENSMUSP00000124258 Ensembl | MGI Sequence Detail 1969 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1924669
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:370814 Chen L, et al., EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase-3 and Aifm1 Splicing Pathways. Adv Sci (Weinh). 2025 May 31;:e04200
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory