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Dcaf13 Gene Detail
Summary
  • Symbol
    Dcaf13
  • Name
    DDB1 and CUL4 associated factor 13
  • Synonyms
    LOC223499, Wdsof1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684929
    NCBI Gene: 223499
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:38976300-39010251 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 15.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    381 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684929
 protein coding gene Chr15:38976260-39010251 (+)
129S1/SvImJ ENSMUSG00200026747
 protein coding gene Chr15:35976475-36010666 (+)
A/J ENSMUSG00195033322
 protein coding gene Chr15:35912264-35946257 (+)
AKR/J ENSMUSG00220026670
 protein coding gene Chr15:35826312-35860304 (+)
BALB/cJ ENSMUSG00180031422
 protein coding gene Chr15:35883760-35917757 (+)
C3H/HeJ ENSMUSG00175026474
 protein coding gene Chr15:36077953-36112000 (+)
C57BL/6NJ ENSMUSG00215018598
 protein coding gene Chr15:35890220-35924209 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019757
 protein coding gene Chr15:33836252-33870264 (+)
CAST/EiJ ENSTCUG00005010429
 protein coding gene Chr15:35904750-35939362 (+)
CBA/J ENSMUSG00210017924
 protein coding gene Chr15:36006007-36039996 (+)
DBA/2J ENSMUSG00185034126
 protein coding gene Chr15:35986853-36020846 (+)
FVB/NJ ENSMUSG00205024996
 protein coding gene Chr15:35876642-35910635 (+)
JF1/MsJ ENSUMUG00000021907
 protein coding gene Chr15:35874791-35908985 (+)
LP/J ENSMUSG00230012015
 protein coding gene Chr15:39357279-39392056 (+)
NOD/ShiLtJ ENSMUSG00190024615
 protein coding gene Chr15:35942715-35976760 (+)
NZO/HlLtJ ENSMUSG00225030660
 protein coding gene Chr15:39665126-39699119 (+)
PWK/PhJ ENSLUMG00010029311
 protein coding gene Chr15:36024856-36059041 (+)
SPRET/EiJ ENSMSPG00010012204
 protein coding gene Chr15:36679707-36727388 (+)
WSB/EiJ ENSIUOG00005030287
 protein coding gene Chr15:35991909-36025954 (+)



Homology
more
  • Human Ortholog
    DCAF13, DDB1 and CUL4 associated factor 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCAF13, DDB1 and CUL4 associated factor 13
  • Synonyms
    GM83, HSPC064, Sof1, WDSOF1
  • Links
    NCBI Gene ID: 25879
    UniProt: Q9NV06

  • Chr Location
    8q22.3; chr8:103414714-103443579 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit pre-implantation lethality with failure of morula compaction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    632
  • Tissues
    13
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 223499 NCBI Gene Model | MGI Sequence Detail 33952 C57BL/6J ±  kb
    transcript NM_198606 RefSeq | MGI Sequence Detail 1511 C57BL/6  
    polypeptide Q6PAC3 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1
      Antibodies 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 12
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:378771 Liu L, et al., The E3 Ubiquitin Ligase DCAF13 Is Essential for Craniofacial Development. Genesis. 2026 Feb;64(1):e70039
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory