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Phactr2 Gene Detail
Summary
  • Symbol
    Phactr2
  • Name
    phosphatase and actin regulator 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446138
    NCBI Gene: 215789
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:13083461-13350156 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 4.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7180 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446138
 protein coding gene Chr10:13083461-13350266 (-)
129S1/SvImJ ENSMUSG00200010076
 protein coding gene Chr10:10090006-10357048 (-)
A/J ENSMUSG00195006712
 protein coding gene Chr10:10016313-10283246 (-)
AKR/J ENSMUSG00220010058
 protein coding gene Chr10:10112924-10385245 (-)
BALB/cJ ENSMUSG00180014435
 protein coding gene Chr10:10173272-10440183 (-)
C3H/HeJ ENSMUSG00175019171
 protein coding gene Chr10:10169515-10436417 (-)
C57BL/6NJ ENSMUSG00215003494
 protein coding gene Chr10:10034325-10301025 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015124
 protein coding gene Chr10:9487993-9752197 (-)
CAST/EiJ ENSTCUG00005029187
 protein coding gene Chr10:10031019-10297901 (-)
CBA/J ENSMUSG00210015350
 protein coding gene Chr10:10119278-10386166 (-)
DBA/2J ENSMUSG00185007070
 protein coding gene Chr10:10156021-10434472 (-)
FVB/NJ ENSMUSG00205015080
 protein coding gene Chr10:10211444-10478498 (-)
JF1/MsJ ENSUMUG00000010888
 protein coding gene Chr10:10198354-10476894 (-)
LP/J ENSMUSG00230018082
 protein coding gene Chr10:11772614-12039505 (-)
NOD/ShiLtJ ENSMUSG00190010411
 protein coding gene Chr10:10145796-10412668 (-)
NZO/HlLtJ ENSMUSG00225015625
 protein coding gene Chr10:16276391-16543447 (-)
PWK/PhJ ENSLUMG00010019637
 protein coding gene Chr10:9950708-10225936 (-)
SPRET/EiJ ENSMSPG00010010778
 protein coding gene Chr10:10351187-10620681 (-)
WSB/EiJ ENSIUOG00005012884
 protein coding gene Chr10:9748692-10015974 (-)



Homology
more
  • Human Ortholog
    PHACTR2, phosphatase and actin regulator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHACTR2, phosphatase and actin regulator 2
  • Synonyms
    C6orf56
  • Links
    NCBI Gene ID: 9749
    UniProt: O75167

  • Chr Location
    6q24.2; chr6:143536845-143831185 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PHACTR2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    993
  • Tissues
    38
  • cDNA Data
    6
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062866 Ensembl Gene Model | MGI Sequence Detail 266696 C57BL/6J ±  kb
transcript ENSMUST00000105546 Ensembl | MGI Sequence Detail 2808 Not Applicable  
polypeptide ENSMUSP00000101185 Ensembl | MGI Sequence Detail 632 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • InterPro Domains
    IPR004018 RPEL repeat
  • GlyGen
    B1AVP0 1 site
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2143783
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:390750 Allen PB, et al., Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7187-92
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory