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Zc3h12a Gene Detail
Summary
  • Symbol
    Zc3h12a
  • Name
    zinc finger CCCH type containing 12A
  • Synonyms
    Mcpip1, MGC:41320, Reg1, Regnase-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385891
    NCBI Gene: 230738
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:125012216-125021633 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 58.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    254 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385891
 protein coding gene Chr4:125012207-125021674 (-)
129S1/SvImJ ENSMUSG00200011205
 protein coding gene Chr4:118443962-118453378 (-)
A/J ENSMUSG00195027705
 protein coding gene Chr4:119772049-119781467 (-)
AKR/J ENSMUSG00220021679
 protein coding gene Chr4:118750478-118759918 (-)
BALB/cJ ENSMUSG00180043575
 protein coding gene Chr4:117419215-117428631 (-)
C3H/HeJ ENSMUSG00175022624
 protein coding gene Chr4:118432113-118441529 (-)
C57BL/6NJ ENSMUSG00215038369
 protein coding gene Chr4:119924764-119934183 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026462
 protein coding gene Chr4:114888938-114898568 (-)
CAST/EiJ ENSTCUG00005042491
 protein coding gene Chr4:119289460-119298885 (-)
CBA/J ENSMUSG00210051894
 protein coding gene Chr4:118060964-118070380 (-)
DBA/2J ENSMUSG00185041566
 protein coding gene Chr4:119593613-119603029 (-)
FVB/NJ ENSMUSG00205014286
 protein coding gene Chr4:117796353-117805770 (-)
JF1/MsJ ENSUMUG00000021681
 protein coding gene Chr4:120224712-120234162 (-)
LP/J ENSMUSG00230029501
 protein coding gene Chr4:123381769-123391185 (-)
NOD/ShiLtJ ENSMUSG00190041503
 protein coding gene Chr4:117796059-117805475 (-)
NZO/HlLtJ ENSMUSG00225016084
 protein coding gene Chr4:129285833-129295260 (-)
PWK/PhJ ENSLUMG00010045459
 protein coding gene Chr4:117243760-117253186 (-)
SPRET/EiJ ENSMSPG00010040193
 protein coding gene Chr4:119321677-119331082 (-)
WSB/EiJ ENSIUOG00005045743
 protein coding gene Chr4:117654440-117663859 (-)



Homology
more
  • Human Ortholog
    ZC3H12A, zinc finger CCCH-type containing 12A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZC3H12A, zinc finger CCCH-type containing 12A
  • Synonyms
    dJ423B22.1, MCPIP, MCPIP-1, MCPIP1, Reg1
  • Links
    NCBI Gene ID: 80149
    UniProt: Q5D1E8

  • Chr Location
    1p34.3; chr1:37474496-37484379 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Zc3h12a mouse models; 1 with human ZC3H12A associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 4 alleles in 5 genetic backgrounds
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit splenomegaly, lymphadenopathy, hyperimmunoglobulinemia, increased auto-antibodies, and defective IL6 post-transcriptional regulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    175
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    16
  • cDNA Data
    18
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042677 Ensembl Gene Model | MGI Sequence Detail 9418 C57BL/6J ±  kb
    transcript ENSMUST00000036188 Ensembl | MGI Sequence Detail 2755 Not Applicable  
    polypeptide ENSMUSP00000037172 Ensembl | MGI Sequence Detail 596 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 131
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 21
      Phenotypes 70
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:389109 Su X, et al., Genetically modulating the RNA-binding protein Regnase-1 reveals its critical role in regulatory T cell homeostasis and function in vivo. Cell Death Dis. 2026 Jul 1;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory