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Tlr3 Gene Detail
Summary
  • Symbol
    Tlr3
  • Name
    toll-like receptor 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156367
    NCBI Gene: 142980
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:45848702-45864112 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 25.31 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2156367
 protein coding gene Chr8:45848702-45864117 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033576
 protein coding gene Chr8:44444713-44459534 (-)
A/J MGP_AJ_G0033558
 protein coding gene Chr8:42740636-42756188 (-)
AKR/J MGP_AKRJ_G0033483
 protein coding gene Chr8:43990329-44005906 (-)
BALB/cJ MGP_BALBcJ_G0033555
 protein coding gene Chr8:42904670-42919778 (-)
C3H/HeJ MGP_C3HHeJ_G0033264
 protein coding gene Chr8:44517865-44533928 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034071
 protein coding gene Chr8:46134001-46153968 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031020
 protein coding gene Chr8:39038725-39052915 (-)
CAST/EiJ MGP_CASTEiJ_G0032590
 protein coding gene Chr8:43936322-43953453 (-)
CBA/J MGP_CBAJ_G0033243
 protein coding gene Chr8:47991068-48007909 (-)
DBA/2J MGP_DBA2J_G0033396
 protein coding gene Chr8:42546648-42561571 (-)
FVB/NJ MGP_FVBNJ_G0033337
 protein coding gene Chr8:42039708-42054173 (-)
LP/J MGP_LPJ_G0033484
 protein coding gene Chr8:44457205-44473683 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033382
 protein coding gene Chr8:48063040-48079217 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034089
 protein coding gene Chr8:44153138-44168839 (-)
PWK/PhJ MGP_PWKPhJ_G0032298
 protein coding gene Chr8:42075953-42091373 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032134
 protein coding gene Chr8:43313369-43328076 (-)
WSB/EiJ MGP_WSBEiJ_G0032706
 protein coding gene Chr8:44403774-44419361 (-)



Homology
more
  • Human Ortholog
    TLR3, toll like receptor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLR3, toll like receptor 3
  • Synonyms
    CD283, IIAE2, IMD83
  • Links
    NCBI Gene ID: 7098
    neXtProt AC: NX_O15455
    UniProt: O15455

  • Chr Location
    4q35.1; chr4:186068911-186088073 (+)  GRCh38
Human Diseases
more
  • Diseases
    7 with human TLR3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 4 alleles in 9 genetic backgrounds
    2 phenotypes from multigenic genotypes
    309 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show alterations in innate immunity against different viruses, viral pathogenesis, anxiety, hippocampal synaptic plasticity, memory retention and neurogenesis. Homozygotes for another null allele show altered ds-RNA responses in dendritic and aorta smooth muscle cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    96
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    31
  • cDNA Data
    24
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 142980 NCBI Gene Model | MGI Sequence Detail 15411 C57BL/6J ±  kb
    transcript NM_126166 RefSeq | MGI Sequence Detail 4407 C57BL/6  
    polypeptide Q99MB1 UniProt | EBI | MGI Sequence Detail 905 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 24
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142652
    References
    more
    • Summaries
      All 480
      Developmental Gene Expression 13
      Gene Ontology 26
      Phenotypes 309
    • Earliest
      J:30988 Bogerd AM, et al., Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase. Mol Endocrinol. 1990 Jun;4(6):845-50
    • Latest
      J:346727 Gollmann-Tepekoylu C, et al., Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification. Circulation. 2023 May 16;147(20):1518-1533
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory