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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tlr3
toll-like receptor 3
MGI:2156367
51 phenotypes from 4 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tlr3M1Btlr/Tlr3+
C57BL/6J-Tlr3M1Btlr 		decreased macrophage cytokine production J:224670
decreased tumor necrosis factor secretion J:224670
Tlr3M1Btlr/Tlr3M1Btlr
C57BL/6J-Tlr3M1Btlr 		decreased macrophage cytokine production J:224670
decreased tumor necrosis factor secretion J:224670
Tlr3M2Btlr/Tlr3+
C57BL/6J-Tlr3M2Btlr 		decreased tumor necrosis factor secretion J:254925
Tlr3M2Btlr/Tlr3M2Btlr
C57BL/6J-Tlr3M2Btlr 		decreased tumor necrosis factor secretion J:254925
Tlr3tm1Aki/Tlr3tm1Aki
involves: 129P2/OlaHsd 		abnormal dendritic cell physiology J:114555
abnormal vascular smooth muscle physiology J:116310
normal immune system phenotype J:144400
Tlr3tm1Flv/Tlr3tm1Flv
B6.129S1-Tlr3tm1Flv/Apb 		abnormal axon morphology J:127638
abnormal cytokine level J:129533
abnormal interleukin level J:126415
abnormal neuron physiology J:127638
abnormal respiratory system physiology J:126415
abnormal righting response J:127638
decreased interferon-beta secretion J:251008
delayed wound healing J:169762
increased tumor incidence J:158910
Tlr3tm1Flv/Tlr3tm1Flv
B6N.129S1-Tlr3tm1Flv/J 		abnormal respiratory function J:288471
increased susceptibility to Coronaviridae infection J:288471
Tlr3tm1Flv/Tlr3tm1Flv
involves: 129S1/Sv 		abnormal cytokine level J:119967
abnormal interferon level J:119967
abnormal interleukin level J:119967
abnormal pancreatic beta cell physiology J:135353
abnormal pancreatic islet morphology J:148283
abnormal postimplantation uterine environment J:164980
abnormal pregnancy J:164980
abnormal tumor necrosis factor level J:119967
decreased pancreatic beta cell mass J:148283
decreased susceptibility to Riboviria infection J:136330
decreased susceptibility to Riboviria infection induced morbidity/mortality J:136330
heart inflammation J:119967
hyperglycemia J:135353
increased circulating troponin I level J:119967
increased pancreatic islet number J:148283
increased susceptibility to Picornaviridae infection induced morbidity/mortality J:119967
Tlr3tm1Flv/Tlr3tm1Flv
involves: 129S1/Sv * C57BL/6 		abnormal B cell physiology J:72167
abnormal dentate gyrus morphology J:163748
abnormal emotion/affect behavior J:163748
abnormal fear-related response J:163748
abnormal hippocampus CA1 region morphology J:163748
abnormal hippocampus development J:163748
abnormal learning/memory/conditioning J:163748
abnormal long-term spatial reference memory J:163748
abnormal macrophage physiology J:72167
abnormal response to novel object J:163748
abnormal spatial working memory J:163748
abnormal vascular wound healing J:169238
decreased anxiety-related response J:163748
decreased fear-related response J:163748
decreased inflammatory response J:72167
normal immune system phenotype J:72167
impaired coordination J:163748
increased fear-related response J:163748
Tlr3tm1Flv/Tlr3tm1Flv
involves: C57BL/6 		abnormal macrophage physiology J:86617
normal immune system phenotype J:86617
Tlr3tm1Flv/Tlr3tm1Flv
Not Specified 		abnormal cytokine secretion J:88906
abnormal NK cell physiology J:88906
abnormal NK T cell physiology J:88906
increased susceptibility to Herpesvirales infection J:88906
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory