Tlr3^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr3^M2Btlr
• Name: toll-like receptor 3; mutation 2, Bruce Beutler
• MGI ID: MGI:6113649
• Synonyms: Ultraman
• Gene: Tlr3 Location: Chr8:45848702-45864112 bp, - strand Genetic Position: Chr8, 25.31 cM, cytoband B2
• Alliance: Tlr3^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 45,402,981 (v38) on chromosome 8, or base pair 8,969 in the GenBank genomic region NC_000074. The mutation corresponds to residue 522 in the mRNA sequence NM_126166 within exon 4 of 7 total exons. The mutation results in an isoleucine (I) to lysine (K) substitution at position 54 (I54K) in the protein. (J:254925)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr3 Mutation: 66 strains or lines available

References

• Original: J:254925 Sun L, et al., Mutagenetix entry for Ultraman. MGI Direct Data Submission. 2018
• All: 1 reference(s)