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Cyp2c50 Gene Detail
Summary
  • Symbol
    Cyp2c50
  • Name
    cytochrome P450, family 2, subfamily c, polypeptide 50
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147497
    NCBI Gene: 107141
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:40078132-40102394 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 34.24 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    924 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147497
 protein coding gene Chr19:40078123-40102399 (+)
129S1/SvImJ ENSMUSG00200027550
 protein coding gene Chr19:36823887-36847002 (+)
A/J ENSMUSG00195010841
 protein coding gene Chr19:36923760-36946876 (+)
AKR/J ENSMUSG00220018328
 protein coding gene Chr19:36726315-36749431 (+)
BALB/cJ ENSMUSG00180030327
 protein coding gene Chr19:37176186-37199301 (+)
C3H/HeJ ENSMUSG00175034590
 protein coding gene Chr19:36696756-36725753 (+)
C57BL/6NJ ENSMUSG00215021139
 protein coding gene Chr19:36766663-36790925 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022936
 protein coding gene Chr19:36808615-36833885 (+)
CAST/EiJ ENSTCUG00005014647
 protein coding gene Chr19:36384536-36407250 (+)
CBA/J ENSMUSG00210029287
 protein coding gene Chr19:36778950-36807947 (+)
DBA/2J ENSMUSG00185029703
 protein coding gene Chr19:37299109-37328106 (+)
FVB/NJ ENSMUSG00205006120
 protein coding gene Chr19:36248057-36271172 (+)
JF1/MsJ ENSUMUG00000034191
 protein coding gene Chr19:37473285-37496397 (+)
LP/J ENSMUSG00230034697
 protein coding gene Chr19:38094094-38117209 (+)
NOD/ShiLtJ ENSMUSG00190010537
 protein coding gene Chr19:36655053-36678168 (+)
NZO/HlLtJ ENSMUSG00225043266
 protein coding gene Chr19:41643915-41667030 (+)
PWK/PhJ ENSLUMG00010001057
 protein coding gene Chr19:36639922-36663063 (+)
SPRET/EiJ ENSMSPG00010022388
 protein coding gene Chr19:36401448-36424405 (+)
WSB/EiJ ENSIUOG00005038129
 protein coding gene Chr19:36168049-36191160 (+)



Homology
more
  • Human Ortholog
    CYP2C18, cytochrome P450 family 2 subfamily C member 18
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP2C18, cytochrome P450 family 2 subfamily C member 18
  • Synonyms
    CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17
  • Links
    NCBI Gene ID: 1562
    UniProt: P33260

  • Chr Location
    10q23.33; chr10:94682944-94736190 (+)  GRCh38
  • Human Ortholog
    CYP2C19, cytochrome P450 family 2 subfamily C member 19
  • Synonyms
    CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19
  • Links
    NCBI Gene ID: 1557
    UniProt: P33261

  • Chr Location
    10q23.33; chr10:94762662-94856282 (+)  GRCh38
  • Human Ortholog
    CYP2C8, cytochrome P450 family 2 subfamily C member 8
  • Synonyms
    CPC8, CYP2C8DM, CYPIIC8, MP-12/MP-20
  • Links
    NCBI Gene ID: 1558
    UniProt: P10632

  • Chr Location
    10q23.33; chr10:95034359-95069498 (-)  GRCh38
  • Human Ortholog
    CYP2C9, cytochrome P450 family 2 subfamily C member 9
  • Synonyms
    CPC9, CYP2C, CYP2C10, CYPIIC9, P450-2C9, P450IIC9
  • Links
    NCBI Gene ID: 1559
    UniProt: P11712

  • Chr Location
    10q23.33; chr10:94938588-94990148 (+)  GRCh38
Human Diseases
more
  • Diseases
    21 with human CYP2C19,CYP2C8,CYP2C9 associations

Human Disease Mouse Models
      
IDs
IDs
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IDs
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IDs
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IDs
IDs
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IDs
IDs
IDs
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IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    49
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054827 Ensembl Gene Model | MGI Sequence Detail 24263 C57BL/6J ±  kb
transcript ENSMUST00000080171 Ensembl | MGI Sequence Detail 1812 Not Applicable  
polypeptide ENSMUSP00000079065 Ensembl | MGI Sequence Detail 490 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    cDNA 49

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:113341 Wang H, et al., Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities. Mol Pharmacol. 2004 May;65(5):1148-58
  • Latest
    J:358008 Zhang D, et al., Suppression of hepatic ChREBP-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH. Mol Metab. 2024 May 11;85:101957
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory