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Akna Gene Detail
Summary
  • Symbol
    Akna
  • Name
    AT-hook transcription factor
  • Synonyms
    mKIAA1968
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140340
    NCBI Gene: 100182
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:63285362-63321591 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 33.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1255 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140340
 protein coding gene Chr4:63285362-63328988 (-)
129S1/SvImJ ENSMUSG00200003050
 protein coding gene Chr4:58258983-58295806 (-)
A/J ENSMUSG00195008048
 protein coding gene Chr4:58842097-58878324 (-)
AKR/J ENSMUSG00220005350
 protein coding gene Chr4:58650842-58687670 (-)
BALB/cJ ENSMUSG00180029568
 protein coding gene Chr4:57827950-57864178 (-)
C3H/HeJ ENSMUSG00175021632
 protein coding gene Chr4:58610714-58646948 (-)
C57BL/6NJ ENSMUSG00215019612
 protein coding gene Chr4:58681959-58718191 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026091
 protein coding gene Chr4:57482855-57519524 (-)
CAST/EiJ ENSTCUG00005007815
 protein coding gene Chr4:58435198-58471780 (-)
CBA/J ENSMUSG00210005781
 protein coding gene Chr4:58361774-58398595 (-)
DBA/2J ENSMUSG00185017759
 protein coding gene Chr4:58783617-58819860 (-)
FVB/NJ ENSMUSG00205014708
 protein coding gene Chr4:57050816-57087644 (-)
JF1/MsJ ENSUMUG00000024044
 protein coding gene Chr4:59424271-59460651 (-)
LP/J ENSMUSG00230009802
 protein coding gene Chr4:62268891-62305711 (-)
NOD/ShiLtJ ENSMUSG00190033181
 protein coding gene Chr4:57760431-57797254 (-)
NZO/HlLtJ ENSMUSG00225013395
 protein coding gene Chr4:67297079-67333906 (-)
PWK/PhJ ENSLUMG00010007296
 protein coding gene Chr4:57051105-57087555 (-)
SPRET/EiJ ENSMSPG00010032037
 protein coding gene Chr4:58328649-58364182 (-)
WSB/EiJ ENSIUOG00005020733
 protein coding gene Chr4:58116173-58152844 (-)



Homology
more
  • Human Ortholog
    AKNA, AT-hook transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKNA, AT-hook transcription factor
  • Links
    NCBI Gene ID: 80709
    UniProt: Q7Z591

  • Chr Location
    9q32; chr9:114330504-114398472 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic or a knock-out allele exhibit partial postnatal lethality, pathogen-induced acute neutrophil responses leading to systemic inflammation and alveolar destruction, and increased susceptibility to fungal infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    845
  • Tissues
    156
  • cDNA Data
    43
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039158 Ensembl Gene Model | MGI Sequence Detail 36230 C57BL/6J ±  kb
    transcript ENSMUST00000035724 Ensembl | MGI Sequence Detail 5387 Not Applicable  
    polypeptide ENSMUSP00000041614 Ensembl | MGI Sequence Detail 1404 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 1
      cDNA 43
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 4
    • Earliest
      J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory