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Lbr Gene Detail
Summary
  • Symbol
    Lbr
  • Name
    lamin B receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138281
    NCBI Gene: 98386
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:181642880-181669933 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 84.89 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    752 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138281
 protein coding gene Chr1:181642880-181670611 (-)
129S1/SvImJ ENSMUSG00200022347
 protein coding gene Chr1:179403433-179426648 (-)
A/J ENSMUSG00195039945
 protein coding gene Chr1:179000966-179024250 (-)
AKR/J ENSMUSG00220019778
 protein coding gene Chr1:178255573-178278787 (-)
BALB/cJ ENSMUSG00180035912
 protein coding gene Chr1:179054737-179077962 (-)
C3H/HeJ ENSMUSG00175033953
 protein coding gene Chr1:179230460-179253681 (-)
C57BL/6NJ ENSMUSG00215015479
 protein coding gene Chr1:178456177-178479404 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014995
 protein coding gene Chr1:171692024-171719341 (-)
CAST/EiJ ENSTCUG00005041342
 protein coding gene Chr1:176982419-177006222 (-)
CBA/J ENSMUSG00210018345
 protein coding gene Chr1:178895474-178918688 (-)
DBA/2J ENSMUSG00185033668
 protein coding gene Chr1:183514890-183538104 (-)
FVB/NJ ENSMUSG00205028679
 protein coding gene Chr1:177946021-177969237 (-)
JF1/MsJ ENSUMUG00000003827
 protein coding gene Chr1:182494137-182518216 (-)
LP/J ENSMUSG00230028755
 protein coding gene Chr1:183062717-183085938 (-)
NOD/ShiLtJ ENSMUSG00190032160
 protein coding gene Chr1:178917525-178940806 (-)
NZO/HlLtJ ENSMUSG00225009626
 protein coding gene Chr1:186818694-186842610 (-)
PWK/PhJ ENSLUMG00010015911
 protein coding gene Chr1:177761497-177784790 (-)
SPRET/EiJ ENSMSPG00010032499
 protein coding gene Chr1:181230114-181259040 (-)
WSB/EiJ ENSIUOG00005010656
 protein coding gene Chr1:178111266-178134526 (-)



Homology
more
  • Human Ortholog
    LBR, lamin B receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LBR, lamin B receptor
  • Synonyms
    C14SR, DHCR14B, LMN2R, PHA, PHASK, TDRD18
  • Links
    NCBI Gene ID: 3930
    UniProt: Q14739

  • Chr Location
    1q42.12; chr1:225400900-225428925 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Lbr mouse models; 3 with human LBR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    112 phenotypes from 7 alleles in 9 genetic backgrounds
    15 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in abnormal skin and hair and impair growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    642
  • Tissues
    40
  • cDNA Data
    176
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 98386 NCBI Gene Model | MGI Sequence Detail 27054 C57BL/6J ±  kb
    transcript NM_001421194 RefSeq | MGI Sequence Detail 4059 ZRU/MplStud  
    polypeptide Q3U9G9 UniProt | EBI | MGI Sequence Detail 626 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 177
      cDNA 176
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11144, MGI:96390
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 21
      Phenotypes 46
    • Earliest
      J:13065 Carter TC, et al., Ichthyosis, a new recessive mutant in the house mouse. J Hered. 1950;41(11):297-300
    • Latest
      J:382969 Huang TC, et al., Global reorganization of genome architecture at the transition to gametogenesis. Nat Struct Mol Biol. 2026 Mar;33(3):433-447
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory