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Tm6sf2 Gene Detail
Summary
  • Symbol
    Tm6sf2
  • Name
    transmembrane 6 superfamily member 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933210
    NCBI Gene: 107770
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70525574-70532716 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    217 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933210
 protein coding gene Chr8:70525574-70532716 (+)
129S1/SvImJ ENSMUSG00200026550
 protein coding gene Chr8:65325022-65332123 (+)
A/J ENSMUSG00195014813
 protein coding gene Chr8:65655106-65662248 (+)
AKR/J ENSMUSG00220024964
 protein coding gene Chr8:65570304-65577418 (+)
BALB/cJ ENSMUSG00180022832
 protein coding gene Chr8:65301412-65308509 (+)
C3H/HeJ ENSMUSG00175020867
 protein coding gene Chr8:65581382-65588479 (+)
C57BL/6NJ ENSMUSG00215028823
 protein coding gene Chr8:65257938-65265080 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031127
 protein coding gene Chr8:62278205-62285270 (+)
CAST/EiJ ENSTCUG00005034035
 protein coding gene Chr8:65055484-65062628 (+)
CBA/J ENSMUSG00210031867
 protein coding gene Chr8:65346935-65354032 (+)
DBA/2J ENSMUSG00185011062
 protein coding gene Chr8:71506557-71513654 (+)
FVB/NJ ENSMUSG00205017743
 protein coding gene Chr8:64851150-64858251 (+)
JF1/MsJ ENSUMUG00000031020
 protein coding gene Chr8:73783863-73790997 (+)
LP/J ENSMUSG00230026383
 protein coding gene Chr8:75118034-75125527 (+)
NOD/ShiLtJ ENSMUSG00190019710
 protein coding gene Chr8:65264581-65271723 (+)
NZO/HlLtJ ENSMUSG00225046009
 protein coding gene Chr8:78527697-78535186 (+)
PWK/PhJ ENSLUMG00010028208
 protein coding gene Chr8:65242410-65249536 (+)
SPRET/EiJ ENSMSPG00010033934
 protein coding gene Chr8:66932647-66939623 (+)
WSB/EiJ ENSIUOG00005020457
 protein coding gene Chr8:66137773-66144879 (+)



Homology
more
  • Human Ortholog
    TM6SF2, transmembrane 6 superfamily member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TM6SF2, transmembrane 6 superfamily member 2
  • Links
    NCBI Gene ID: 53345
    UniProt: Q9BZW4

  • Chr Location
    19p13.11; chr19:19264109-19273391 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show hepatosteatosis, hypocholesterolemia, increased serum alanine transaminase level, reduced VLDL-TG secretion, small VLDL particles, and lipid accumulation in enterocytes. Homozygotes for another null allele show reduced total cholesterol and LDL cholesterol levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    2
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107770 NCBI Gene Model | MGI Sequence Detail 7143 C57BL/6J ±  kb
    transcript NM_001293795 RefSeq | MGI Sequence Detail 1446 C57BL/6  
    polypeptide Q8R1J1 UniProt | EBI | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 3
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 19
    • Earliest
      J:66727 Carim-Todd L, et al., Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24-->q26 and 19p13.3-->p12. Cytogenet Cell Genet. 2000;90(3-4):255-60
    • Latest
      J:364054 Zhang X, et al., Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut-liver axis. Nat Metab. 2025 Jan;7(1):102-119
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory