Tm6sf2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tm6sf2
transmembrane 6 superfamily member 2
MGI:1933210

16 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tm6sf2^em1Yech/Tm6sf2^em1Yech C57BL/6-Tm6sf2^em1Yech	abnormal cholesterol homeostasis	J:235704
	decreased circulating cholesterol level	J:235704
	decreased circulating HDL cholesterol level	J:235704
	decreased circulating LDL cholesterol level	J:235704
	normal homeostasis/metabolism phenotype	J:235704
	increased circulating triglyceride level	J:235704
	normal liver/biliary system phenotype	J:235704
Tm6sf2^{tm1a(KOMP)Wtsi}/Tm6sf2⁺ C57BL/6N-Tm6sf2^{tm1a(KOMP)Wtsi}	abnormal cholesterol homeostasis	J:234195
	increased liver triglyceride level	J:234195
Tm6sf2^{tm1a(KOMP)Wtsi}/Tm6sf2^{tm1a(KOMP)Wtsi} C57BL/6N-Tm6sf2^{tm1a(KOMP)Wtsi}	abnormal cholesterol homeostasis	J:234195
	abnormal circulating apolipoprotein level	J:234195
	abnormal enterocyte morphology	J:234195
	abnormal intestinal lipid absorption	J:234195
	decreased circulating cholesterol level	J:234195
	decreased circulating HDL cholesterol level	J:234195
	decreased circulating LDL cholesterol level	J:234195
	decreased circulating VLDL triglyceride level	J:234195
	decreased intestinal cholesterol absorption	J:234195
	hepatic steatosis	J:234195
	increased circulating alanine transaminase level	J:234195
	increased circulating triglyceride level	J:234195
	increased liver triglyceride level	J:234195
	increased triglyceride level	J:234195

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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