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Cdk5rap3 Gene Detail
Summary
  • Symbol
    Cdk5rap3
  • Name
    CDK5 regulatory subunit associated protein 3
  • Synonyms
    1810007E24Rik, C53, HSF-27, IC53, MGC:8303, MST016, OK/SW-cl.114
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933126
    NCBI Gene: 80280
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96798252-96807322 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 60.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933126
 protein coding gene Chr11:96798251-96807359 (-)
129S1/SvImJ ENSMUSG00200052907
 protein coding gene Chr11:94047373-94049306 (-)
129S1/SvImJ ENSMUSGG00200054993
 protein coding gene Chr11:94051479-94051842 (-)
A/J ENSMUSGG00195055529
 protein coding gene Chr11:93771178-93771541 (-)
A/J ENSMUSG00195051147
 protein coding gene Chr11:93767268-93769188 (-)
AKR/J ENSMUSG00220044928
 protein coding gene Chr11:94026414-94028334 (-)
AKR/J ENSMUSGG00220054941
 protein coding gene Chr11:94030344-94030707 (-)
BALB/cJ ENSMUSG00180045438
 protein coding gene Chr11:94032098-94034029 (-)
BALB/cJ ENSMUSGG00180055635
 protein coding gene Chr11:94036202-94036565 (-)
C3H/HeJ ENSMUSGG00175055189
 protein coding gene Chr11:94031753-94032116 (-)
C3H/HeJ ENSMUSG00175047294
 protein coding gene Chr11:94027649-94029580 (-)
C57BL/6NJ ENSMUSGG00215055827
 protein coding gene Chr11:93624521-93624884 (-)
C57BL/6NJ ENSMUSG00215050824
 protein coding gene Chr11:93620414-93622347 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017039
 protein coding gene Chr11:92678781-92687397 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210052847
 protein coding gene Chr11:93729517-93731437 (-)
CBA/J ENSMUSGG00210055135
 protein coding gene Chr11:93733427-93733790 (-)
DBA/2J ENSMUSG00185043695
 protein coding gene Chr11:94077531-94079462 (-)
DBA/2J ENSMUSGG00185057989
 protein coding gene Chr11:94081635-94081998 (-)
FVB/NJ ENSMUSG00205038052
 protein coding gene Chr11:93934319-93936251 (-)
FVB/NJ ENSMUSGG00205054706
 protein coding gene Chr11:93938425-93938788 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230048454
 protein coding gene Chr11:95130367-95132299 (-)
LP/J ENSMUSGG00230055919
 protein coding gene Chr11:95134472-95134835 (-)
NOD/ShiLtJ ENSMUSG00190049663
 protein coding gene Chr11:94125643-94127573 (-)
NOD/ShiLtJ ENSMUSGG00190055135
 protein coding gene Chr11:94129746-94130109 (-)
NZO/HlLtJ ENSMUSG00225049166
 protein coding gene Chr11:97185758-97187689 (-)
NZO/HlLtJ ENSMUSGG00225055716
 protein coding gene Chr11:97189862-97190225 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CDK5RAP3, CDK5 regulatory subunit associated protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK5RAP3, CDK5 regulatory subunit associated protein 3
  • Synonyms
    C53, HSF-27, IC53, LZAP, MST016, OK/SW-cl.114, PP1553
  • Links
    NCBI Gene ID: 80279
    UniProt: Q96JB5

  • Chr Location
    17q21.32; chr17:47967810-47981781 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 2 alleles in 4 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete fetal lethality, anemia, hypoplastic liver, abnormal liver development and impaired erythropoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    107
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    690
  • Tissues
    22
  • cDNA Data
    149
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018669 Ensembl Gene Model | MGI Sequence Detail 9071 C57BL/6J ±  kb
    transcript ENSMUST00000103152 Ensembl | MGI Sequence Detail 2250 Not Applicable  
    polypeptide ENSMUSP00000099441 Ensembl | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000005263 CDK5 regulatory subunit-associated protein 3
      (term hierarchy)
    • InterPro Domains
      IPR008491 CDK5 regulatory subunit-associated protein 3
    • GlyGen
      Q99LM2 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 151
      cDNA 150
      Primer pair 1
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913515, MGI:2144672
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:367469 Yang S, et al., UFMylation safeguards human hepatocyte differentiation and liver homeostasis by regulating ribosome dissociation. Cell Rep. 2025 May 27;44(5):115686
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory