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Ucn3 Gene Detail
Summary
  • Symbol
    Ucn3
  • Name
    urocortin 3
  • Synonyms
    Urocortin III
Location &
Maps
more
  • Sequence Map
    Chr13:3990688-3995349 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 2.20 cM, cytoband A1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932970
 protein coding gene Chr13:3990688-3995349 (-)
129S1/SvImJ ENSMUSG00200005556
 protein coding gene Chr13:1172579-1177240 (-)
A/J ENSMUSG00195012201
 protein coding gene Chr13:580746-585407 (-)
AKR/J ENSMUSG00220012963
 protein coding gene Chr13:861730-866389 (-)
BALB/cJ ENSMUSG00180008873
 protein coding gene Chr13:992935-997596 (-)
C3H/HeJ ENSMUSG00175008220
 protein coding gene Chr13:1012639-1017300 (-)
C57BL/6NJ ENSMUSG00215010504
 protein coding gene Chr13:1232459-1237124 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018199
 protein coding gene Chr13:447585-452325 (-)
CAST/EiJ ENSTCUG00005024060
 protein coding gene Chr13:1235708-1240366 (-)
CBA/J ENSMUSG00210022700
 protein coding gene Chr13:551350-556009 (-)
DBA/2J ENSMUSG00185023633
 protein coding gene Chr13:1239073-1243734 (-)
FVB/NJ ENSMUSG00205018018
 protein coding gene Chr13:994586-999251 (-)
JF1/MsJ ENSUMUG00000005675
 protein coding gene Chr13:1249050-1253738 (-)
LP/J ENSMUSG00230007229
 protein coding gene Chr13:10721520-10726196 (-)
NOD/ShiLtJ ENSMUSG00190012959
 protein coding gene Chr13:698979-703640 (-)
NZO/HlLtJ ENSMUSG00225034260
 protein coding gene Chr13:4609197-4613879 (-)
PWK/PhJ ENSLUMG00010016610
 protein coding gene Chr13:613673-618357 (-)
SPRET/EiJ ENSMSPG00010021152
 protein coding gene Chr13:655840-660485 (-)
WSB/EiJ ENSIUOG00005021275
 protein coding gene Chr13:586684-591345 (-)



Homology
more
  • Human Ortholog
    UCN3, urocortin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UCN3, urocortin 3
  • Synonyms
    SCP, SPC, UCNIII
  • Links
    NCBI Gene ID: 114131
    UniProt: Q969E3

  • Chr Location
    10p15.1; chr10:5364966-5374692 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele are protected from the hyperinsulinemia, hyperglycemia, glucose intolerance, hepatic steatosis and hypertriglyceridemia induced by a high-fat diet, and show better glucose tolerance as they age. Mice homozygous for another null allele show improved social memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    642
  • Tissues
    15
  • cDNA Data
    7
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83428 NCBI Gene Model | MGI Sequence Detail 4662 C57BL/6J ±  kb
    transcript NM_031250 RefSeq | MGI Sequence Detail 1478 C57BL/6  
    polypeptide Q924A4 UniProt | EBI | MGI Sequence Detail 164 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Other 1
      Antibodies 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 25
      Gene Ontology 12
      Phenotypes 21
    • Earliest
      J:67860 Reyes TM, et al., Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2843-8
    • Latest
      J:390194 Park J, et al., PAX4 R192H variant impairs beta cell function by disrupting beta cell identity and compensatory capacity in response to metabolic stress. Genome Med. 2026 May 28;18(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory