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Celf4 Gene Detail
Summary
  • Symbol
    Celf4
  • Name
    CUGBP, Elav-like family member 4
  • Synonyms
    A230070D14Rik, Brul4, Brunol4, BRUNOL-4, C130060B05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932407
    NCBI Gene: 108013
  • Alliance
    genome feature page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:25610689-25887214 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 13.92 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6940 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932407
 protein coding gene Chr18:25610677-25887577 (-)
129S1/SvImJ ENSMUSG00200015780
 protein coding gene Chr18:22608330-22884807 (-)
A/J ENSMUSG00195002144
 protein coding gene Chr18:22776037-23052710 (-)
AKR/J ENSMUSG00220010855
 protein coding gene Chr18:22764306-23040770 (-)
BALB/cJ ENSMUSG00180003108
 protein coding gene Chr18:23216284-23492933 (-)
C3H/HeJ ENSMUSG00175023743
 protein coding gene Chr18:22740222-23019728 (-)
C57BL/6NJ ENSMUSG00215020416
 protein coding gene Chr18:22468018-22744632 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022058
 protein coding gene Chr18:22438263-22715402 (-)
CAST/EiJ ENSTCUG00005014957
 protein coding gene Chr18:22447662-22725233 (-)
CBA/J ENSMUSG00210016076
 protein coding gene Chr18:22766981-23043610 (-)
DBA/2J ENSMUSG00185021813
 protein coding gene Chr18:22715008-22991681 (-)
FVB/NJ ENSMUSG00205018872
 protein coding gene Chr18:22433842-22710209 (-)
JF1/MsJ ENSUMUG00000024619
 protein coding gene Chr18:22808168-23086361 (-)
LP/J ENSMUSG00230005363
 protein coding gene Chr18:24804155-25080634 (-)
NOD/ShiLtJ ENSMUSG00190006936
 protein coding gene Chr18:22523796-22800298 (-)
NZO/HlLtJ ENSMUSG00225025365
 protein coding gene Chr18:24767106-25043701 (-)
PWK/PhJ ENSLUMG00010003329
 protein coding gene Chr18:22991383-23275484 (-)
SPRET/EiJ ENSMSPG00010022103
 protein coding gene Chr18:22901703-23168860 (-)
WSB/EiJ ENSIUOG00005002573
 protein coding gene Chr18:22547378-22823800 (-)



Homology
more
  • Human Ortholog
    CELF4, CUGBP Elav-like family member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CELF4, CUGBP Elav-like family member 4
  • Synonyms
    BRUNOL4, CELF-4
  • Links
    NCBI Gene ID: 56853
    UniProt: Q9BZC1

  • Chr Location
    18q12.2; chr18:37242844-37565994 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 13 genetic backgrounds
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality, shortened life span dependent on genetic background, and seizures. Mice heterozygous for a null allele exhibit complex seizures and abnormal body weights depending on age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    794
  • Tissues
    81
  • cDNA Data
    15
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024268 Ensembl Gene Model | MGI Sequence Detail 276526 C57BL/6J ±  kb
    transcript ENSMUST00000115816 Ensembl | MGI Sequence Detail 3995 Not Applicable  
    polypeptide ENSMUSP00000111483 Ensembl | MGI Sequence Detail 504 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 15
      Primer pair 9
      Other 2
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442678, MGI:2444528
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 11
      Gene Ontology 12
      Phenotypes 21
    • Earliest
      J:19671 Yulug IG, et al., Mapping GRB2, a signal transduction gene in the human and the mouse. Genomics. 1994 Jul 15;22(2):313-8
    • Latest
      J:377636 Mueth MG, et al., The RNA-binding protein CELF4 is a negative regulator of sensory neuron excitability and mechanical and heat behavioral sensitivity. Neurobiol Pain. 2025 Jul-Dec;18:100184
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory