Dstyk MGI Mouse Gene Detail - MGI:1925064 - dual serine/threonine and tyrosine protein kinase

Symbol

Dstyk
Name

dual serine/threonine and tyrosine protein kinase
Synonyms

A930019K20Rik, C430014H23Rik

Feature Type

protein coding gene
IDs

MGI:1925064
NCBI Gene: 213452
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:132345293-132394696 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.24 cM, cytoband E4
Mapping Data

2 experiments

SNPs within 2kb

1228 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925064	protein coding gene	Chr1:132345127-132394697 (+)
129S1/SvImJ	ENSMUSG00200007893	protein coding gene	Chr1:129908883-129958401 (+)
A/J	ENSMUSG00195042064	protein coding gene	Chr1:129010079-129059552 (+)
AKR/J	ENSMUSG00220046604	protein coding gene	Chr1:128840113-128889629 (+)
BALB/cJ	ENSMUSG00180031186	protein coding gene	Chr1:129556171-129605687 (+)
C3H/HeJ	ENSMUSG00175037528	protein coding gene	Chr1:129254614-129304083 (+)
C57BL/6NJ	ENSMUSG00215043488	protein coding gene	Chr1:129270377-129319784 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014587	protein coding gene	Chr1:124006550-124056729 (+)
CAST/EiJ	ENSTCUG00005032971	protein coding gene	Chr1:128176993-128225990 (+)
CBA/J	ENSMUSG00210025293	protein coding gene	Chr1:129150947-129200455 (+)
DBA/2J	ENSMUSG00185030619	protein coding gene	Chr1:133507668-133557181 (+)
FVB/NJ	ENSMUSG00205035323	protein coding gene	Chr1:128487348-128536870 (+)
JF1/MsJ	ENSUMUG00000020142	protein coding gene	Chr1:132674676-132723849 (+)
LP/J	ENSMUSG00230035833	protein coding gene	Chr1:133095398-133144805 (+)
NOD/ShiLtJ	ENSMUSG00190042026	protein coding gene	Chr1:129164601-129214076 (+)
NZO/HlLtJ	ENSMUSG00225016509	protein coding gene	Chr1:136815604-136865020 (+)
PWK/PhJ	ENSLUMG00010025926	protein coding gene	Chr1:128285108-128334523 (+)
SPRET/EiJ	ENSMSPG00010044814	protein coding gene	Chr1:131088623-131139863 (+)
WSB/EiJ	ENSIUOG00005043327	protein coding gene	Chr1:128896891-128946348 (+)

Human Ortholog

DSTYK, dual serine/threonine and tyrosine protein kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DSTYK, dual serine/threonine and tyrosine protein kinase
Synonyms

CAKUT1, DustyPK, HDCMD38P, RHDNS1, RIP5, RIPK5, SPG23
Links

HGNC:29043

NCBI Gene ID: 25778

UniProt: Q6XUX3
Chr Location

1q32.1; chr1:205142505-205211709 (-) GRCh38

MGI Vertebrate Homology

Dstyk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DSTYK
Gene Tree

Dstyk

Diseases

2 with human DSTYK associations

				Human Disease	Mouse Models
				congenital anomalies of the kidney and urinary tract 1 IDs congenital anomalies of the kidney and urinary tract 1 DOID:0080206 OMIM:610805
				hereditary spastic paraplegia 23 IDs hereditary spastic paraplegia 23 DOID:0110774 ICD10CM:G11.4 OMIM:270750 ORDO:101003

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

2
Endonuclease-mediated

6
Gene trapped

7
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Dstyk
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

71 strains or lines available

Homozygous knockout results in impaired spatial learning.

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All GO Annotations

40
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

850
Tissues

79
cDNA Data

17
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dstyk

ZFIN dstyk

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All Sequences

80
RefSeq

7
UniProt

5
CCDS

CCDS15285.1

Ensembl

ENSMUSG00000042046 (Evidence)
NCBI Gene

213452

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042046	Ensembl Gene Model \| MGI Sequence Detail	49404	C57BL/6J	± kb
transcript	ENSMUST00000045110	Ensembl \| MGI Sequence Detail	6282	Not Applicable
polypeptide	ENSMUSP00000035358	Ensembl \| MGI Sequence Detail	927	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006714 dual serine/threonine and tyrosine protein kinase

(term hierarchy)
EC

2.7.11.1, 2.7.12.1
InterPro Domains

IPR051302 Dual serine/threonine and tyrosine protein kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q6XUX1 1 site, 1 N-linked glycan (1 site)

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All nucleic 17

cDNA 17

Antibodies 2

Microarray probesets 6

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MGI:1926105

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Dstyk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8744	Chr1:132345115-132345140 (+)	-165 bp
Tssr8745	Chr1:132345147-132345202 (+)	-118 bp
Tssr8746	Chr1:132345293-132345347 (+)	27 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24