Tmem106a MGI Mouse Gene Detail - MGI:1922056

Symbol

Tmem106a
Name

transmembrane protein 106A
Synonyms

0610008L10Rik, MGC:30290, MGC:37887

Feature Type

protein coding gene
IDs

MGI:1922056
NCBI Gene: 217203
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:101473068-101482612 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 65.44 cM
Mapping Data

3 experiments

SNPs within 2kb

364 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922056	protein coding gene	Chr11:101473068-101482614 (+)
129S1/SvImJ	ENSMUSG00200049929	protein coding gene	Chr11:98743233-98752777 (+)
A/J	ENSMUSG00195051474	protein coding gene	Chr11:98436841-98446398 (+)
AKR/J	ENSMUSG00220047459	protein coding gene	Chr11:98673469-98683026 (+)
BALB/cJ	ENSMUSG00180047812	protein coding gene	Chr11:98805697-98815246 (+)
C3H/HeJ	ENSMUSG00175043161	protein coding gene	Chr11:98716761-98726310 (+)
C57BL/6NJ	ENSMUSG00215052772	protein coding gene	Chr11:98293100-98302649 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017225	protein coding gene	Chr11:97462187-97470026 (+)
CAST/EiJ	ENSTCUG00005049826	protein coding gene	Chr11:98212560-98222098 (+)
CBA/J	ENSMUSG00210053153	protein coding gene	Chr11:98438944-98448490 (+)
DBA/2J	ENSMUSG00185044964	protein coding gene	Chr11:98766621-98776169 (+)
FVB/NJ	ENSMUSG00205049188	protein coding gene	Chr11:98623797-98633349 (+)
JF1/MsJ	ENSUMUG00000026120	protein coding gene	Chr11:99031418-99040962 (+)
LP/J	ENSMUSG00230045056	protein coding gene	Chr11:99819256-99828804 (+)
NOD/ShiLtJ	ENSMUSG00190037807	protein coding gene	Chr11:98805190-98814736 (+)
NZO/HlLtJ	ENSMUSG00225051821	protein coding gene	Chr11:101855133-101864694 (+)
PWK/PhJ	ENSLUMG00010040375	protein coding gene	Chr11:98573872-98583718 (+)
SPRET/EiJ	ENSMSPG00010047398	protein coding gene	Chr11:99055869-99064817 (+)
WSB/EiJ	ENSIUOG00005044850	protein coding gene	Chr11:98567061-98576602 (+)

Human Ortholog

TMEM106A, transmembrane protein 106A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM106A, transmembrane protein 106A
Links

HGNC:28288

NCBI Gene ID: 113277

UniProt: Q96A25
Chr Location

17q21.31; chr17:43211835-43220041 (+) GRCh38

MGI Vertebrate Homology

Tmem106a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM106A
Gene Tree

Tmem106a

less

Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

6
Gene trapped

9
Targeted

3
Genomic Mutations

1 involving Tmem106a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show increased sensitivity to lipopolysaccharide (LPS)-induced septic shock and cecal ligation puncture treatment, along with enhanced M1-type polarization of macrophages and increased LPS-induced inflammation via the MAPK and NF-kappaB signaling pathways.

less

All GO Annotations

6
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

70

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN tmem106a

less

All Sequences

60
RefSeq

8
UniProt

3
CCDS

CCDS25476.1

Ensembl

ENSMUSG00000034947 (Evidence)
NCBI Gene

217203

			Length	Strain/Species	Flank
genomic	217203	NCBI Gene Model \| MGI Sequence Detail	9545	C57BL/6J	± kb
transcript	NM_001359325	RefSeq \| MGI Sequence Detail	2544	C57BL/6
polypeptide	Q8VC04	UniProt \| EBI \| MGI Sequence Detail	261	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000031524 transmembrane protein 106A

(term hierarchy)
InterPro Domains

IPR009790 Transmembrane protein 106

IPR048509 Transmembrane protein 106, C-terminal domain

IPR048511 Transmembrane protein 106, N-terminal
GlyGen

Q8VC04 1 site, 1 N-linked glycan (1 site)

less

All nucleic 70

cDNA 70

Microarray probesets 5

less

MGI:2144065, MGI:2384951

Summaries

All 45

Gene Ontology 3

Phenotypes 16
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tmem106a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105141	Chr11:101473062-101473138 (+)	32 bp
Tssr105142	Chr11:101474242-101474302 (+)	1,204 bp
Tssr105143	Chr11:101474310-101474320 (+)	1,247 bp
Tssr105144	Chr11:101474399-101474419 (+)	1,341 bp
Tssr105145	Chr11:101474437-101474456 (+)	1,379 bp
Tssr105146	Chr11:101474548-101474559 (+)	1,486 bp
Tssr105147	Chr11:101475263-101475303 (+)	2,215 bp
Tssr105148	Chr11:101477058-101477148 (+)	4,035 bp
Tssr105149	Chr11:101478741-101478790 (+)	5,698 bp
Tssr105150	Chr11:101479732-101479750 (+)	6,673 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29