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Stx11 Gene Detail
Summary
  • Symbol
    Stx11
  • Name
    syntaxin 11
  • Synonyms
    5830405C08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921982
    NCBI Gene: 74732
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:12813953-12840042 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 4.54 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1159 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921982
 protein coding gene Chr10:12813953-12840242 (-)
129S1/SvImJ ENSMUSG00200009861
 protein coding gene Chr10:9827350-9853431 (-)
A/J no annotation
AKR/J ENSMUSG00220007422
 protein coding gene Chr10:9850085-9876032 (-)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ ENSMUSG00215005105
 protein coding gene Chr10:9761246-9787332 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015119
 protein coding gene Chr10:9214597-9238825 (-)
CAST/EiJ ENSTCUG00005017658
 protein coding gene Chr10:9760365-9786236 (-)
CBA/J ENSMUSG00210012481
 protein coding gene Chr10:9840224-9866241 (-)
DBA/2J ENSMUSG00185009753
 protein coding gene Chr10:9868141-9894653 (-)
FVB/NJ ENSMUSG00205007675
 protein coding gene Chr10:9948849-9974838 (-)
JF1/MsJ ENSUMUG00000018386
 protein coding gene Chr10:9910384-9936850 (-)
LP/J ENSMUSG00230018363
 protein coding gene Chr10:11503038-11529271 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ ENSMUSG00225015677
 protein coding gene Chr10:16013738-16039822 (-)
PWK/PhJ ENSLUMG00010020553
 protein coding gene Chr10:9680933-9707362 (-)
SPRET/EiJ ENSMSPG00010010696
 protein coding gene Chr10:10076970-10102761 (-)
WSB/EiJ ENSIUOG00005013390
 protein coding gene Chr10:9470109-9502456 (-)



Homology
more
  • Human Ortholog
    STX11, syntaxin 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STX11, syntaxin 11
  • Synonyms
    FHL4, HLH4, HPLH4
  • Links
    NCBI Gene ID: 8676
    UniProt: O75558

  • Chr Location
    6q24.2; chr6:144139963-144191939 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Stx11 mouse models; 1 with human STX11 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defective CTL degranulation and symptoms of hemophagocytic lymphohistiocytosis following infection with LMCV.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    702
  • Tissues
    14
  • cDNA Data
    18
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039232 Ensembl Gene Model | MGI Sequence Detail 26090 C57BL/6J ±  kb
    transcript ENSMUST00000042861 Ensembl | MGI Sequence Detail 4173 Not Applicable  
    polypeptide ENSMUSP00000046243 Ensembl | MGI Sequence Detail 287 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 11
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:380177 Li B, et al., Palmitoylated STX11 suppresses AMPK to drive lipogenesis and colorectal cancer. Biochim Biophys Acta Mol Cell Biol Lipids. 2026 Jan 30;1871(3):159730
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory