Stx11^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Stx11^tm1.2Ics
• Name: syntaxin 11; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:5476622
• Gene: Stx11 Location: Chr10:12813953-12840042 bp, - strand Genetic Position: Chr10, 4.54 cM, cytoband A2
• Alliance: Stx11^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193137
• Parent Cell Line: BD10 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A resistance cassette (FRT site, neo resistance gene, loxP site, FRT site and loxP site) was inserted downstream of exon 3. An additional loxP site was inserted upstream of exon 3. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of protein expression in CD8+ T cells. (J:193137)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stx11 Mutation: 7 strains or lines available

References

• Original: J:193137 Sepulveda FE, et al., Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11. Blood. 2013 Jan 24;121(4):595-603
• All: 3 reference(s)