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Dnm1l Gene Detail
Summary
  • Symbol
    Dnm1l
  • Name
    dynamin 1-like
  • Synonyms
    6330417M19Rik, Dnmlp1, Drp1, python
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921256
    NCBI Gene: 74006
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:16130094-16176823 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    839 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921256
 protein coding gene Chr16:16130092-16176863 (-)
129S1/SvImJ ENSMUSG00200043502
 protein coding gene Chr16:13126523-13173246 (-)
A/J ENSMUSG00195033705
 protein coding gene Chr16:12683455-12730184 (-)
AKR/J ENSMUSG00220042526
 protein coding gene Chr16:12999696-13046426 (-)
BALB/cJ ENSMUSG00180030336
 protein coding gene Chr16:12924788-12971511 (-)
C3H/HeJ ENSMUSG00175037603
 protein coding gene Chr16:13069785-13116514 (-)
C57BL/6NJ ENSMUSG00215034305
 protein coding gene Chr16:12790894-12837623 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020492
 protein coding gene Chr16:12814698-12862402 (-)
CAST/EiJ ENSTCUG00005040035
 protein coding gene Chr16:12949702-12996478 (-)
CBA/J ENSMUSG00210045973
 protein coding gene Chr16:13086143-13132872 (-)
DBA/2J ENSMUSG00185030267
 protein coding gene Chr16:13032263-13078992 (-)
FVB/NJ ENSMUSG00205029658
 protein coding gene Chr16:13040901-13087633 (-)
JF1/MsJ ENSUMUG00000048304
 protein coding gene Chr16:13084220-13131861 (-)
LP/J ENSMUSG00230039784
 protein coding gene Chr16:15610214-15656943 (-)
NOD/ShiLtJ ENSMUSG00190045610
 protein coding gene Chr16:13172209-13218938 (-)
NZO/HlLtJ ENSMUSG00225031216
 protein coding gene Chr16:18855986-18902715 (-)
PWK/PhJ ENSLUMG00010048230
 protein coding gene Chr16:12958153-13005215 (-)
SPRET/EiJ ENSMSPG00010042976
 protein coding gene Chr16:12989318-13032700 (-)
WSB/EiJ ENSIUOG00005037864
 protein coding gene Chr16:13143432-13190120 (-)



Homology
more
  • Human Ortholog
    DNM1L, dynamin 1L
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNM1L, dynamin 1L
  • Synonyms
    DLP1, DRP1, DVLP, DYMPLE, EMPF, EMPF1, HDYNIV, OPA5
  • Links
    NCBI Gene ID: 10059
    UniProt: O00429

  • Chr Location
    12p11.21; chr12:32679200-32745650 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dnm1l mouse models; 2 with human DNM1L associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    80 phenotypes from 7 alleles in 10 genetic backgrounds
    6 images
    111 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality at E11.5 with internal hemorrhage and small size. Mice heterozygous for an ENU induced allele have dilated cardiomyopathy and congestive heart failure, homozygous are embryonic lethal with posterior truncation at E11.5. Brain isoform-specific KO results in ectopic dendrite growth in the hippocampus and enhanced sensorimotor gating.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    192
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    639
  • Tissues
    12
  • cDNA Data
    26
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022789 Ensembl Gene Model | MGI Sequence Detail 46730 C57BL/6J ±  kb
    transcript ENSMUST00000230980 Ensembl | MGI Sequence Detail 2151 Not Applicable  
    polypeptide ENSMUSP00000155155 Ensembl | MGI Sequence Detail 716 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 26
      Primer pair 1
      Antibodies 4

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1195987, MGI:2146435
    References
    more
    • Summaries
      All 313
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 31
      Phenotypes 111
    • Earliest
      J:45166 Kamimoto T, et al., Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells. J Biol Chem. 1998 Jan 9;273(2):1044-51
    • Latest
      J:386086 Ma AM, et al., Drp1 regulates mitochondrial health and controls skeletal muscle mass through the Erk1/2-Nur77 pathway. Sci Adv. 2026 May 8;12(19):eaec0795
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory