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Naalad2 Gene Detail
Summary
  • Symbol
    Naalad2
  • Name
    N-acetylated alpha-linked acidic dipeptidase 2
  • Synonyms
    D9Ertd285e, Folh1b, GCP3, GCPIII, NAADALASE2, NAALADASE2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919810
    NCBI Gene: 72560
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:18233247-18308834 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.02 cM, cytoband A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2100 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919810
 protein coding gene Chr9:18233247-18314291 (-)
129S1/SvImJ ENSMUSG00200046853
 protein coding gene Chr9:15099626-15165838 (-)
A/J ENSMUSG00195032099
 protein coding gene Chr9:15023242-15089496 (-)
AKR/J ENSMUSG00220028615
 protein coding gene Chr9:15001759-15068010 (-)
BALB/cJ ENSMUSG00180034118
 protein coding gene Chr9:15151317-15217564 (-)
C3H/HeJ ENSMUSG00175037611
 protein coding gene Chr9:15120010-15186271 (-)
C57BL/6NJ ENSMUSG00215025216
 protein coding gene Chr9:15113015-15179255 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031804
 protein coding gene Chr9:14302731-14386546 (-)
CAST/EiJ ENSTCUG00005028994
 protein coding gene Chr9:15045232-15114467 (-)
CBA/J ENSMUSG00210034657
 protein coding gene Chr9:15101375-15167583 (-)
DBA/2J ENSMUSG00185023402
 protein coding gene Chr9:15216712-15282964 (-)
FVB/NJ ENSMUSG00205020323
 protein coding gene Chr9:15331278-15397498 (-)
JF1/MsJ ENSUMUG00000016776
 protein coding gene Chr9:15178238-15242697 (-)
LP/J ENSMUSG00230037408
 protein coding gene Chr9:15597809-15664022 (-)
NOD/ShiLtJ ENSMUSG00190032726
 protein coding gene Chr9:15132167-15198403 (-)
NZO/HlLtJ ENSMUSG00225049418
 protein coding gene Chr9:15486019-15552227 (-)
PWK/PhJ ENSLUMG00010043809
 protein coding gene Chr9:15123751-15194801 (-)
SPRET/EiJ ENSMSPG00010021821
 protein coding gene Chr9:15338569-15413013 (-)
WSB/EiJ ENSIUOG00005036004
 protein coding gene Chr9:14665396-14731626 (-)



Homology
more
  • Human Ortholog
    NAALAD2, N-acetylated alpha-linked acidic dipeptidase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAALAD2, N-acetylated alpha-linked acidic dipeptidase 2
  • Synonyms
    GCP3, GCPIII, GPCIII
  • Links
    NCBI Gene ID: 10003
    UniProt: Q9Y3Q0

  • Chr Location
    11q14.3; chr11:90131515-90192894 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele do not display reduction in responses to traumatic brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    26
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 72560 NCBI Gene Model | MGI Sequence Detail 75588 C57BL/6J ±  kb
transcript NM_001357399 RefSeq | MGI Sequence Detail 6233 C57BL/6  
polypeptide Q9CZR2 UniProt | EBI | MGI Sequence Detail 740 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 26
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1098761
References
more
  • Summaries
    All 39
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:346617 Sedlak F, et al., Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition. ACS Chem Neurosci. 2024 Feb 20;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory