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Dusp11 Gene Detail
Summary
  • Symbol
    Dusp11
  • Name
    dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
  • Synonyms
    2010300F21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919352
    NCBI Gene: 72102
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:85919250-85938649 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    448 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919352
 protein coding gene Chr6:85919250-85938950 (-)
129S1/SvImJ ENSMUSG00200042939
 protein coding gene Chr6:82875855-82895240 (-)
A/J ENSMUSG00195038178
 protein coding gene Chr6:82560164-82579552 (-)
AKR/J ENSMUSG00220027632
 protein coding gene Chr6:81470696-81490091 (-)
BALB/cJ ENSMUSG00180014954
 protein coding gene Chr6:82945539-82964939 (-)
C3H/HeJ ENSMUSG00175037037
 protein coding gene Chr6:94449762-94469168 (+)
C57BL/6NJ ENSMUSG00215024639
 protein coding gene Chr6:82940935-82960342 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028588
 protein coding gene Chr6:82005352-82014264 (-)
CAST/EiJ ENSTCUG00005017995
 protein coding gene Chr6:82876530-82895866 (-)
CBA/J ENSMUSG00210037541
 protein coding gene Chr6:82751344-82770736 (-)
DBA/2J ENSMUSG00185043321
 protein coding gene Chr6:83298490-83317876 (-)
FVB/NJ ENSMUSG00205025808
 protein coding gene Chr6:81929357-81948739 (-)
JF1/MsJ ENSUMUG00000033897
 protein coding gene Chr6:82244175-82263641 (-)
LP/J ENSMUSG00230047095
 protein coding gene Chr6:84432505-84451887 (-)
NOD/ShiLtJ ENSMUSG00190042643
 protein coding gene Chr6:82375112-82394490 (-)
NZO/HlLtJ ENSMUSG00225018868
 protein coding gene Chr6:86396340-86415751 (-)
PWK/PhJ ENSLUMG00010006226
 protein coding gene Chr6:81655367-81674735 (-)
SPRET/EiJ ENSMSPG00010031937
 protein coding gene Chr6:83811441-83829983 (-)
WSB/EiJ ENSIUOG00005031145
 protein coding gene Chr6:83280343-83299718 (-)



Homology
more
  • Human Ortholog
    DUSP11, dual specificity phosphatase 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DUSP11, dual specificity phosphatase 11
  • Synonyms
    PIR1
  • Links
    NCBI Gene ID: 8446
    UniProt: O75319

  • Chr Location
    2p13.1; chr2:73761782-73780173 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased mortality and cytokine production in response to LPS-induced endotoxic shock. Bone marrow-derived macrophages show enhanced LPS-induced macrophage activation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    640
  • Tissues
    29
  • cDNA Data
    174
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030002 Ensembl Gene Model | MGI Sequence Detail 19400 C57BL/6J ±  kb
    transcript ENSMUST00000032071 Ensembl | MGI Sequence Detail 6435 Not Applicable  
    polypeptide ENSMUSP00000032071 Ensembl | MGI Sequence Detail 321 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 175
      cDNA 175

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141428
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory