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Jmjd1c Gene Detail
Summary
  • Symbol
    Jmjd1c
  • Name
    jumonji domain containing 1C
  • Synonyms
    5430433L24Rik, D630035I23Rik, TRIP8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918614
    NCBI Gene: 108829
  • Alliance
    genome feature page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:66932189-67092105 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 34.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2875 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918614
 protein coding gene Chr10:66931904-67092105 (+)
129S1/SvImJ ENSMUSG00200017158
 protein coding gene Chr10:63628290-63788937 (+)
A/J ENSMUSG00195005569
 protein coding gene Chr10:63922503-64083162 (+)
AKR/J ENSMUSG00220025321
 protein coding gene Chr10:63591342-63752008 (+)
BALB/cJ ENSMUSG00180007432
 protein coding gene Chr10:63957065-64117719 (+)
C3H/HeJ ENSMUSG00175011556
 protein coding gene Chr10:63791692-63952333 (+)
C57BL/6NJ ENSMUSG00215003395
 protein coding gene Chr10:63566582-63727234 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015407
 protein coding gene Chr10:61297967-61453595 (+)
CAST/EiJ ENSTCUG00005024612
 protein coding gene Chr10:63525405-63686249 (+)
CBA/J ENSMUSG00210009201
 protein coding gene Chr10:63671481-63832107 (+)
DBA/2J ENSMUSG00185019567
 protein coding gene Chr10:64034286-64194928 (+)
FVB/NJ ENSMUSG00205007095
 protein coding gene Chr10:63738128-63898753 (+)
JF1/MsJ ENSUMUG00000014397
 protein coding gene Chr10:65231896-65392686 (+)
LP/J ENSMUSG00230017405
 protein coding gene Chr10:65800666-65961293 (+)
NOD/ShiLtJ ENSMUSG00190007934
 protein coding gene Chr10:64032527-64193142 (+)
NZO/HlLtJ ENSMUSG00225044683
 protein coding gene Chr10:70088981-70249633 (+)
PWK/PhJ ENSLUMG00010007666
 protein coding gene Chr10:63630810-63791655 (+)
SPRET/EiJ ENSMSPG00010021975
 protein coding gene Chr10:65306535-65428686 (+)
WSB/EiJ ENSIUOG00005032771
 protein coding gene Chr10:63558470-63719123 (+)



Homology
more
  • Human Ortholog
    JMJD1C, jumonji domain containing 1C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JMJD1C, jumonji domain containing 1C
  • Synonyms
    KDM3C, TRIP-8, TRIP8
  • Links
    NCBI Gene ID: 221037
    UniProt: Q15652

  • Chr Location
    10q21.3; chr10:63167221-63521890 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit an age-dependent male infertility phenotype, characterized by early loss of undifferentiated spermatogonia, and a progressive reduction in testis size/weight and male germ cells, partly due to increased male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    642
  • Tissues
    18
  • cDNA Data
    21
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108829 NCBI Gene Model | MGI Sequence Detail 159917 C57BL/6J ±  kb
    transcript NM_001242396 RefSeq | MGI Sequence Detail 8617 C57BL/6  
    polypeptide Q69ZK6 UniProt | EBI | MGI Sequence Detail 2531 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2444048
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 30
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory