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Prrc2a Gene Detail
Summary
  • Symbol
    Prrc2a
  • Name
    proline-rich coiled-coil 2A
  • Synonyms
    3110039B05Rik, Bat-2, Bat2, D17H6S51E, G2, Wbp12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915467
    NCBI Gene: 53761
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35368052-35383873 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • Strain Annotations
    19
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915467
 protein coding gene Chr17:35368052-35384877 (-)
129S1/SvImJ ENSMUSG00200051011
 protein coding gene Chr17:31072174-31087996 (-)
A/J ENSMUSG00195033841
 protein coding gene Chr17:31974544-31990171 (-)
AKR/J ENSMUSG00220051570
 protein coding gene Chr17:31001405-31017024 (-)
BALB/cJ ENSMUSG00180040673
 protein coding gene Chr17:31344398-31360026 (-)
C3H/HeJ ENSMUSG00175033405
 protein coding gene Chr17:30887511-30903130 (-)
C57BL/6NJ ENSMUSG00215052699
 protein coding gene Chr17:30912396-30928218 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021510
 protein coding gene Chr17:31892145-31907871 (-)
CAST/EiJ ENSTCUG00005050184
 protein coding gene Chr17:31929947-31945560 (-)
CBA/J ENSMUSG00210040376
 protein coding gene Chr17:30709614-30725235 (-)
DBA/2J ENSMUSG00185051828
 protein coding gene Chr17:33363636-33379262 (-)
FVB/NJ ENSMUSG00205052715
 protein coding gene Chr17:31230053-31245660 (-)
JF1/MsJ ENSUMUG00000015333
 protein coding gene Chr17:32614406-32630214 (-)
LP/J ENSMUSG00230054516
 protein coding gene Chr17:34470422-34486243 (-)
NOD/ShiLtJ ENSMUSG00190032995
 protein coding gene Chr17:30830988-30846808 (-)
NZO/HlLtJ ENSMUSG00225054715
 protein coding gene Chr17:36483113-36498701 (-)
PWK/PhJ ENSLUMG00010033167
 protein coding gene Chr17:30449122-30464941 (-)
SPRET/EiJ ENSMSPG00010033571
 protein coding gene Chr17:31632483-31648102 (-)
WSB/EiJ ENSIUOG00005047925
 protein coding gene Chr17:31558362-31573966 (-)



Homology
more
  • Human Ortholog
    PRRC2A, proline rich coiled-coil 2A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRRC2A, proline rich coiled-coil 2A
  • Synonyms
    BAT2, D6S51, D6S51E, G2
  • Links
    NCBI Gene ID: 7916
    UniProt: P48634

  • Chr Location
    6p21.33; chr6:31620715-31637771 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRRC2A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in oligodendroglial-lineage cells exhibit reduced reduced weight, increased brain weight, enlarged ventricles, hypomyelination, decreased oligodendrocytes, impaired coordination, decreased grip strength, and impaired spatial learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    226
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024393 Ensembl Gene Model | MGI Sequence Detail 15822 C57BL/6J ±  kb
    transcript ENSMUST00000025253 Ensembl | MGI Sequence Detail 6888 Not Applicable  
    polypeptide ENSMUSP00000025253 Ensembl | MGI Sequence Detail 2158 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 245
      Genomic 14
      cDNA 230
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1500, MGD-MRK-1507, MGD-MRK-4479, MGI:90672
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:2355 Snoek M, et al., Fine mapping of the crossover-sites in the C4-H-2D region of H-2 recombinant mouse strains. Immunogenetics. 1991;34(6):409-12
    • Latest
      J:375923 Li X, et al., Microglial Prrc2a regulates microglia-neuron interaction in cerebellum and motor functions in mice. iScience. 2025 Dec 19;28(12):113949
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory