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Gadd45gip1 Gene Detail
Summary
  • Symbol
    Gadd45gip1
  • Name
    growth arrest and DNA-damage-inducible, gamma interacting protein 1
  • Synonyms
    2310040G17Rik, Crif1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914947
    NCBI Gene: 102060
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85558911-85562111 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914947
 protein coding gene Chr8:85558151-85562111 (+)
129S1/SvImJ ENSMUSG00200024110
 protein coding gene Chr8:79923478-79927444 (+)
A/J ENSMUSG00195014408
 protein coding gene Chr8:80281427-80285621 (+)
AKR/J ENSMUSG00220021820
 protein coding gene Chr8:80323056-80327022 (+)
BALB/cJ ENSMUSG00180019078
 protein coding gene Chr8:80122157-80126124 (+)
C3H/HeJ ENSMUSG00175010712
 protein coding gene Chr8:80217112-80221305 (+)
C57BL/6NJ ENSMUSG00215008669
 protein coding gene Chr8:79854441-79858402 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031309
 protein coding gene Chr8:76166960-76170881 (+)
CAST/EiJ ENSTCUG00005033450
 protein coding gene Chr8:79731756-79735721 (+)
CBA/J ENSMUSG00210020032
 protein coding gene Chr8:80204238-80208431 (+)
DBA/2J ENSMUSG00185036625
 protein coding gene Chr8:86312846-86317039 (+)
FVB/NJ ENSMUSG00205020092
 protein coding gene Chr8:79260057-79264250 (+)
JF1/MsJ ENSUMUG00000015392
 protein coding gene Chr8:88620944-88624905 (+)
LP/J ENSMUSG00230028661
 protein coding gene Chr8:89920479-89924444 (+)
NOD/ShiLtJ ENSMUSG00190026285
 protein coding gene Chr8:80280825-80284791 (+)
NZO/HlLtJ ENSMUSG00225039185
 protein coding gene Chr8:93315157-93319117 (+)
PWK/PhJ ENSLUMG00010027525
 protein coding gene Chr8:79958348-79962315 (+)
SPRET/EiJ ENSMSPG00010024314
 protein coding gene Chr8:81873035-81876994 (+)
WSB/EiJ ENSIUOG00005015613
 protein coding gene Chr8:81018400-81022366 (+)



Homology
more
  • Human Ortholog
    GADD45GIP1, GADD45G interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GADD45GIP1, GADD45G interacting protein 1
  • Synonyms
    CKBBP2, CKbetaBP2, CRIF1, mL64, MRP-L59, PLINP, Plinp1, PLINP-1, PRG6
  • Links
    NCBI Gene ID: 90480
    UniProt: Q8TAE8

  • Chr Location
    19p13.13; chr19:12953119-12957223 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gadd45gip1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality before somite formation with decreased cell proliferation, increased apoptisis, and failure of inner cell mass outgrowth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    635
  • Tissues
    20
  • cDNA Data
    13
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 102060 NCBI Gene Model | MGI Sequence Detail 3201 C57BL/6J ±  kb
    transcript NM_183358 RefSeq | MGI Sequence Detail 1734 C57BL/6  
    polypeptide Q9CR59 UniProt | EBI | MGI Sequence Detail 222 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 13
      Primer pair 3
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2142529
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 61
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:387674 Jin SA, et al., Role of CR6-Interacting Factor 1 (Crif1) in Cardiac Mitochondrial Structure and Stress-Induced Functional Decline. Korean Circ J. 2026 Apr;56(4):314-325
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory