About   Help   FAQ
Sdha Gene Detail
Summary
  • Symbol
    Sdha
  • Name
    succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
  • Synonyms
    2310034D06Rik, FP, SDH2, SDHF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914195
    NCBI Gene: 66945
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:74470374-74498359 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 40.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    967 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914195
 protein coding gene Chr13:74470373-74498399 (-)
129S1/SvImJ ENSMUSG00200011225
 protein coding gene Chr13:68875077-68902956 (-)
A/J ENSMUSG00195028477
 protein coding gene Chr13:69449738-69477620 (-)
AKR/J ENSMUSG00220030813
 protein coding gene Chr13:68040881-68068761 (-)
BALB/cJ ENSMUSG00180021446
 protein coding gene Chr13:69948063-69975942 (-)
C3H/HeJ ENSMUSG00175006918
 protein coding gene Chr13:70226348-70254227 (-)
C57BL/6NJ ENSMUSG00215005735
 protein coding gene Chr13:70014162-70042188 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018720
 protein coding gene Chr13:68980660-69008915 (-)
CAST/EiJ ENSTCUG00005011536
 protein coding gene Chr13:69530022-69558148 (-)
CBA/J ENSMUSG00210008128
 protein coding gene Chr13:69549454-69577480 (-)
DBA/2J ENSMUSG00185017953
 protein coding gene Chr13:73241004-73269030 (-)
FVB/NJ ENSMUSG00205018310
 protein coding gene Chr13:68928262-68956141 (-)
JF1/MsJ ENSUMUG00000015743
 protein coding gene Chr13:73000704-73028827 (-)
LP/J ENSMUSG00230023927
 protein coding gene Chr13:83159674-83187700 (-)
NOD/ShiLtJ ENSMUSG00190033406
 protein coding gene Chr13:69548276-69576155 (-)
NZO/HlLtJ ENSMUSG00225027839
 protein coding gene Chr13:75666829-75694708 (-)
PWK/PhJ ENSLUMG00010011451
 protein coding gene Chr13:69042041-69070055 (-)
SPRET/EiJ ENSMSPG00010029177
 protein coding gene Chr13:69947621-69976167 (-)
WSB/EiJ ENSIUOG00005020217
 protein coding gene Chr13:68800778-68828563 (-)



Homology
more
  • Human Ortholog
    SDHA, succinate dehydrogenase complex flavoprotein subunit A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SDHA, succinate dehydrogenase complex flavoprotein subunit A
  • Synonyms
    CMD1GG, FP, MC2DN1, NDAXOA, PGL5, PPGL5, SDH1, SDH2, SDHF
  • Links
    NCBI Gene ID: 6389
    UniProt: P31040

  • Chr Location
    5p15.33; chr5:218274-268746 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human SDHA associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    155
  • cDNA Data
    423
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66945 NCBI Gene Model | MGI Sequence Detail 27986 C57BL/6J ±  kb
    transcript NM_023281 RefSeq | MGI Sequence Detail 2859 C57BL/6  
    polypeptide Q8K2B3 UniProt | EBI | MGI Sequence Detail 664 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000014563 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
      (term hierarchy)
    • EC
      1.1.5.-, 1.3.5.1
    • InterPro Domains
      IPR003953 FAD-dependent oxidoreductase 2, FAD-binding domain
      IPR030664 FAD-dependent oxidoreductase SdhA/FrdA/AprA
      IPR036188 FAD/NAD(P)-binding domain superfamily
      IPR003952 Fumarate reductase/succinate dehydrogenase, FAD-binding site
      IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
      IPR037099 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily
      IPR011281 Succinate dehydrogenase, flavoprotein subunit
      IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily
      IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
    • GlyGen
      Q8K2B3 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 430
      cDNA 424
      Primer pair 6
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145519
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 33
      Gene Ontology 23
      Phenotypes 24
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:388028 Rueda EM, et al., Electron transport chain activity balances cell cycle progression and differentiation of retinal progenitor cells. Exp Eye Res. 2026 Jun 17;:111127
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory