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Symbol Name ID |
Sdha
succinate dehydrogenase complex, subunit A, flavoprotein (Fp) MGI:1914195 |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased activity of mitochondrial respiratory chain |
Decreased activity of mitochondrial complex I |
Decreased activity of mitochondrial complex II |
Decreased activity of mitochondrial complex III |
Decreased activity of mitochondrial complex IV |
Abnormal mitochondria in muscle tissue |
Decreased activity of the pyruvate dehydrogenase complex |
Hyperalaninemia |
Increased CSF lactate |
Abnormal circulating enzyme concentration or activity |
Decreased circulating biotinidase concentration |
Hypoglycemia |
Increased circulating lactate concentration |
Ketoacidosis |
Lactic acidosis |
Stress/infection-induced lactic acidosis |
Renal tubular acidosis |
Elevated lactate:pyruvate ratio |
Increased intramyocellular lipid droplets |
3-Methylglutaconic aciduria |
Ethylmalonic aciduria |
Methylmalonic aciduria |
Elevated urinary catecholamine level |
Generalized aminoaciduria |
Lacticaciduria |
Complex organic aciduria |
Elevated circulating catecholamine level |
Exercise intolerance |
| Disease(s) Associated with SDHA | ||||||||||||||||||||||||||||
| dilated cardiomyopathy 1GG | ||||||||||||||||||||||||||||
| Leigh disease | ||||||||||||||||||||||||||||
| mitochondrial complex II deficiency | ||||||||||||||||||||||||||||
| paraganglioma |
| Mouse Phenotypes | decreased circulating glucose level |
increased circulating free fatty acids level |
increased circulating sodium level |
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| Availability | Mouse Genotype | |||
| Sdhatm2b(KOMP)Wtsi/Sdha+ | ||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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