About   Help   FAQ
Bccip Gene Detail
Summary
  • Symbol
    Bccip
  • Name
    BRCA2 and CDKN1A interacting protein
  • Synonyms
    1110013J05Rik, TOK-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913415
    NCBI Gene: 66165
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:133311062-133322874 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 77.30 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    502 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913415
 protein coding gene Chr7:133311045-133322874 (+)
129S1/SvImJ ENSMUSG00200026020
 protein coding gene Chr7:119854839-119866695 (+)
A/J ENSMUSG00195036213
 protein coding gene Chr7:124325401-124337257 (+)
AKR/J ENSMUSG00220015572
 protein coding gene Chr7:117786243-117798102 (+)
BALB/cJ ENSMUSG00180013435
 protein coding gene Chr7:121031614-121043470 (+)
C3H/HeJ ENSMUSG00175034322
 protein coding gene Chr7:121757843-121769701 (+)
C57BL/6NJ ENSMUSG00215034374
 protein coding gene Chr7:121028324-121040184 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030589
 protein coding gene Chr7:135898839-135910477 (+)
CAST/EiJ ENSTCUG00005046853
 protein coding gene Chr7:124319927-124331081 (+)
CBA/J ENSMUSG00210030474
 protein coding gene Chr7:121525058-121536917 (+)
DBA/2J ENSMUSG00185023839
 protein coding gene Chr7:125836017-125847871 (+)
FVB/NJ ENSMUSG00205042749
 protein coding gene Chr7:121472142-121483997 (+)
JF1/MsJ ENSUMUG00000016302
 protein coding gene Chr7:130851899-130863114 (+)
LP/J ENSMUSG00230042591
 protein coding gene Chr7:131958588-131970444 (+)
NOD/ShiLtJ ENSMUSG00190020265
 protein coding gene Chr7:121659170-121671026 (+)
NZO/HlLtJ ENSMUSG00225012419
 protein coding gene Chr7:130193388-130205245 (+)
PWK/PhJ ENSLUMG00010028605
 protein coding gene Chr7:120015801-120027016 (+)
SPRET/EiJ ENSMSPG00010010329
 protein coding gene Chr7:121326336-121337539 (+)
WSB/EiJ ENSIUOG00005033908
 protein coding gene Chr7:122340668-122351888 (+)



Homology
more
  • Human Ortholog
    BCCIP, BRCA2 and CDKN1A interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCCIP, BRCA2 and CDKN1A interacting protein
  • Synonyms
    TOK-1, TOK1
  • Links
    NCBI Gene ID: 56647
    UniProt: Q9P287

  • Chr Location
    10q26.2; chr10:125823525-125853695 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous deletion of this gene causes complete embryonic lethality. Mosaic or heterozygous deletion leads to spontaneous development of hepatocellular carcinoma and B-Cell lymphoma at advanced age, with chronic liver and spleen inflammation, and histologic features of nonalcoholic steatohepatitis and Mallory-Denk bodies in non-tumor liver tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    672
  • Tissues
    9
  • cDNA Data
    96
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030983 Ensembl Gene Model | MGI Sequence Detail 11813 C57BL/6J ±  kb
    transcript ENSMUST00000033282 Ensembl | MGI Sequence Detail 1244 Not Applicable  
    polypeptide ENSMUSP00000033282 Ensembl | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 96

      Microarray probesets 2
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:366628 Lu H, et al., Medulloblastomas Initiated by Homologous Recombination Defects in Mice. Am J Pathol. 2024 Nov;194(11):2007-2022
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory