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Rogdi Gene Detail
Summary
  • Symbol
    Rogdi
  • Name
    rogdi homolog
  • Synonyms
    0610011C19Rik, Lzf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913299
    NCBI Gene: 66049
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:4826594-4831417 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.49 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    168 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913299
 protein coding gene Chr16:4826593-4831438 (-)
129S1/SvImJ ENSMUSG00200009301
 protein coding gene Chr16:1818518-1823316 (-)
A/J ENSMUSG00195011057
 protein coding gene Chr16:1367814-1372610 (-)
AKR/J ENSMUSG00220017092
 protein coding gene Chr16:1667901-1672699 (-)
BALB/cJ ENSMUSG00180008264
 protein coding gene Chr16:1619474-1624274 (-)
C3H/HeJ ENSMUSG00175029200
 protein coding gene Chr16:1810708-1815506 (-)
C57BL/6NJ ENSMUSG00215013283
 protein coding gene Chr16:1491964-1496762 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020418
 protein coding gene Chr16:1275743-1281088 (-)
CAST/EiJ ENSTCUG00005029250
 protein coding gene Chr16:1692325-1697110 (-)
CBA/J ENSMUSG00210011960
 protein coding gene Chr16:1828076-1832874 (-)
DBA/2J ENSMUSG00185009752
 protein coding gene Chr16:1773226-1778025 (-)
FVB/NJ ENSMUSG00205010933
 protein coding gene Chr16:1689569-1694367 (-)
JF1/MsJ ENSUMUG00000016593
 protein coding gene Chr16:1815486-1820228 (-)
LP/J ENSMUSG00230010229
 protein coding gene Chr16:4314237-4319036 (-)
NOD/ShiLtJ ENSMUSG00190021451
 protein coding gene Chr16:1852182-1856980 (-)
NZO/HlLtJ ENSMUSG00225023017
 protein coding gene Chr16:7556565-7561363 (-)
PWK/PhJ ENSLUMG00010016726
 protein coding gene Chr16:1681948-1686690 (-)
SPRET/EiJ ENSMSPG00010016797
 protein coding gene Chr16:1627761-1632549 (-)
WSB/EiJ ENSIUOG00005016408
 protein coding gene Chr16:1807283-1812082 (-)



Homology
more
  • Human Ortholog
    ROGDI, rogdi atypical leucine zipper
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ROGDI, rogdi atypical leucine zipper
  • Synonyms
    KTZS, RAV2, ROGD1
  • Links
    NCBI Gene ID: 79641
    UniProt: Q9GZN7

  • Chr Location
    16p13.3; chr16:4796962-4802926 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rogdi mouse models; 1 with human ROGDI associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice lacking exons 6-11 exhibit hyperactivity, memory deficits, increased susceptibility to induced seizures, less mature enamel that is hypomineralized, and recapitulate Kohlschutter-Tonz syndrome.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    81
  • cDNA Data
    106
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022540 Ensembl Gene Model | MGI Sequence Detail 4824 C57BL/6J ±  kb
    transcript ENSMUST00000023191 Ensembl | MGI Sequence Detail 1431 Not Applicable  
    polypeptide ENSMUSP00000023191 Ensembl | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 107
      Primer pair 4
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146556, MGI:2146693
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 9
      Phenotypes 4
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:385562 Winkley SR, et al., The ROGDI protein mutated in Kohlschutter-Tonz syndrome is a novel subunit of the Rabconnectin-3 complex implicated in V-ATPase assembly. J Biol Chem. 2025 Mar 4;301(4):108381
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory