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Tk2 Gene Detail
Summary
  • Symbol
    Tk2
  • Name
    thymidine kinase 2, mitochondrial
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913266
    NCBI Gene: 57813
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:104953317-104975190 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    711 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913266
 protein coding gene Chr8:104953317-104975224 (-)
129S1/SvImJ ENSMUSG00200014180
 protein coding gene Chr8:99251536-99273408 (-)
A/J ENSMUSG00195003814
 protein coding gene Chr8:99534976-99556854 (-)
AKR/J ENSMUSG00220010828
 protein coding gene Chr8:99702327-99724199 (-)
BALB/cJ ENSMUSG00180003851
 protein coding gene Chr8:99560428-99582302 (-)
C3H/HeJ ENSMUSG00175002691
 protein coding gene Chr8:99617203-99639079 (-)
C57BL/6NJ ENSMUSG00215001159
 protein coding gene Chr8:99231504-99253378 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031440
 protein coding gene Chr8:95425124-95449500 (-)
CAST/EiJ ENSTCUG00005022789
 protein coding gene Chr8:99003423-99033401 (-)
CBA/J ENSMUSG00210015219
 protein coding gene Chr8:99545808-99567682 (-)
DBA/2J ENSMUSG00185004750
 protein coding gene Chr8:105653704-105675579 (-)
FVB/NJ ENSMUSG00205011026
 protein coding gene Chr8:98578528-98600398 (-)
JF1/MsJ ENSUMUG00000010866
 protein coding gene Chr8:107986877-108008751 (-)
LP/J ENSMUSG00230005611
 protein coding gene Chr8:109334233-109356107 (-)
NOD/ShiLtJ ENSMUSG00190012432
 protein coding gene Chr8:99683833-99705706 (-)
NZO/HlLtJ ENSMUSG00225021856
 protein coding gene Chr8:112684710-112706584 (-)
PWK/PhJ ENSLUMG00010003931
 protein coding gene Chr8:99507083-99530551 (-)
SPRET/EiJ ENSMSPG00010029117
 protein coding gene Chr8:101616507-101640205 (-)
WSB/EiJ ENSIUOG00005005762
 protein coding gene Chr8:100360404-100383822 (-)



Homology
more
  • Human Ortholog
    TK2, thymidine kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TK2, thymidine kinase 2
  • Synonyms
    MTDPS2, MTTK, PEOB3, SCA31, TK2-EXT
  • Links
    NCBI Gene ID: 7084
    UniProt: O00142

  • Chr Location
    16q21; chr16:66508003-66552544 (-)  GRCh38
  • MGI Vertebrate Homology
    Tk2 stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: TK2
  • Protein SuperFamily
    DNK
  • Gene Tree
    Tk2
Human Diseases
more
  • Diseases
    1 with Tk2 mouse models; 2 with human TK2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knock-out mice die at 2-4 wks of age showing stunted growth, hypothermia, progressive mtDNA loss, aberrant myocardial fibers and altered adipose tissue structure. Knock-in mutant mice show encephalomyelopathy, impaired gait, mtDNA loss, altered mt dNTP pools and respiratory chain enzyme activities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    56
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035824 Ensembl Gene Model | MGI Sequence Detail 21874 C57BL/6J ±  kb
    transcript ENSMUST00000212275 Ensembl | MGI Sequence Detail 1507 Not Applicable  
    polypeptide ENSMUSP00000148642 Ensembl | MGI Sequence Detail 270 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 56

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142713
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 16
      Phenotypes 19
    • Earliest
      J:64961 Wettin K, et al., Cloning of mouse mitochondrial thymidine kinase 2 cDNA. FEBS Lett. 1999 Oct 22;460(1):103-6
    • Latest
      J:367884 Zhao Q, et al., Long term survival and abnormal liver fat accumulation in mice with specific thymidine kinase 2 deficiency in liver tissue. PLoS One. 2023;18(10):e0285242
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory