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Gprc5a Gene Detail
Summary
  • Symbol
    Gprc5a
  • Name
    G protein-coupled receptor, family C, group 5, member A
  • Synonyms
    Gprc5a, Rai3, Raig1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891250
    NCBI Gene: 232431
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:135042660-135061707 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 65.83 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    794 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891250
 protein coding gene Chr6:135042649-135061707 (+)
129S1/SvImJ ENSMUSG00200030094
 protein coding gene Chr6:132537469-132556404 (+)
A/J ENSMUSG00195028641
 protein coding gene Chr6:131398100-131417079 (+)
AKR/J ENSMUSG00220037242
 protein coding gene Chr6:129622519-129641494 (+)
BALB/cJ ENSMUSG00180033486
 protein coding gene Chr6:131469577-131494864 (+)
C3H/HeJ ENSMUSG00175033075
 protein coding gene Chr6:131418460-131437436 (+)
C57BL/6NJ ENSMUSG00215015112
 protein coding gene Chr6:131665311-131684376 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028987
 protein coding gene Chr6:133045257-133066169 (+)
CAST/EiJ ENSTCUG00005037250
 protein coding gene Chr6:132334840-132354244 (+)
CBA/J ENSMUSG00210015573
 protein coding gene Chr6:131436884-131455853 (+)
DBA/2J ENSMUSG00185021635
 protein coding gene Chr6:132133099-132152081 (+)
FVB/NJ ENSMUSG00205027635
 protein coding gene Chr6:130567264-130586178 (+)
JF1/MsJ ENSUMUG00000039685
 protein coding gene Chr6:130881558-130900649 (+)
LP/J ENSMUSG00230007744
 protein coding gene Chr6:133333303-133352239 (+)
NOD/ShiLtJ ENSMUSG00190006464
 protein coding gene Chr6:131971334-131990309 (+)
NZO/HlLtJ ENSMUSG00225007175
 protein coding gene Chr6:136189034-136216225 (+)
PWK/PhJ ENSLUMG00010036628
 protein coding gene Chr6:129939209-129958342 (+)
SPRET/EiJ ENSMSPG00010032147
 protein coding gene Chr6:133730455-133749346 (+)
WSB/EiJ ENSIUOG00005040919
 protein coding gene Chr6:132233069-132252035 (+)



Homology
more
  • Human Ortholog
    GPRC5A, G protein-coupled receptor class C group 5 member A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPRC5A, G protein-coupled receptor class C group 5 member A
  • Synonyms
    GPCR5A, PEIG-1, RAI3, RAIG1, TIG1
  • Links
    NCBI Gene ID: 9052
    UniProt: Q8NFJ5

  • Chr Location
    12p13.1; chr12:12890782-12917937 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele are healthy and exhibit normal lung development and a normal life span. A different homozygous KO allele causes a significantly increased incidence of acidophilic macrophage pneumonia and spontaneous lung tumors at 1-2 years of age. Another different homozygous KO results in age-related and diabetes-related pathology in kidney glomeruli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    55
  • cDNA Data
    4
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232431 NCBI Gene Model | MGI Sequence Detail 19048 C57BL/6J ±  kb
    transcript NM_181444 RefSeq | MGI Sequence Detail 2072 C57BL/6  
    polypeptide Q8BHL4 UniProt | EBI | MGI Sequence Detail 356 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 4
      Primer pair 1
      Other 3
      Antibodies 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 35
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:381227 Peng F, et al., Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions. Cancer Cell. 2026 Feb 9;44(2):321-339.e13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory