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Tnfrsf13b Gene Detail
Summary
  • Symbol
    Tnfrsf13b
  • Name
    tumor necrosis factor receptor superfamily, member 13b
  • Synonyms
    1200009E08Rik, Taci
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889411
    NCBI Gene: 57916
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61017581-61040198 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    736 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889411
 protein coding gene Chr11:61017567-61040435 (+)
129S1/SvImJ ENSMUSG00200035881
 protein coding gene Chr11:57942277-57964851 (+)
A/J ENSMUSG00195032743
 protein coding gene Chr11:57976862-57999475 (+)
AKR/J ENSMUSG00220047610
 protein coding gene Chr11:58084318-58106935 (+)
BALB/cJ ENSMUSG00180043662
 protein coding gene Chr11:58030259-58052884 (+)
C3H/HeJ ENSMUSG00175036184
 protein coding gene Chr11:57994102-58016720 (+)
C57BL/6NJ ENSMUSG00215037524
 protein coding gene Chr11:57737027-57759645 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016470
 protein coding gene Chr11:55956968-55978782 (+)
CAST/EiJ ENSTCUG00005045672
 protein coding gene Chr11:57525148-57547940 (+)
CBA/J ENSMUSG00210030349
 protein coding gene Chr11:57827143-57849764 (+)
DBA/2J ENSMUSG00185040377
 protein coding gene Chr11:58016560-58039189 (+)
FVB/NJ ENSMUSG00205031005
 protein coding gene Chr11:57901370-57924117 (+)
JF1/MsJ ENSUMUG00000048241
 protein coding gene Chr11:58427272-58450186 (+)
LP/J ENSMUSG00230049829
 protein coding gene Chr11:59163558-59186122 (+)
NOD/ShiLtJ ENSMUSG00190051089
 protein coding gene Chr11:58010779-58033407 (+)
NZO/HlLtJ ENSMUSG00225046260
 protein coding gene Chr11:61307024-61329591 (+)
PWK/PhJ ENSLUMG00010034310
 protein coding gene Chr11:57949375-57972160 (+)
SPRET/EiJ ENSMSPG00010027898
 protein coding gene Chr11:58619123-58640368 (+)
WSB/EiJ ENSIUOG00005033840
 protein coding gene Chr11:57934129-57956869 (+)



Homology
more
  • Human Ortholog
    TNFRSF13B, TNF receptor superfamily member 13B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF13B, TNF receptor superfamily member 13B
  • Synonyms
    CD267, CVID, CVID2, IGAD2, RYZN, TACI, TNFRSF14B
  • Links
    NCBI Gene ID: 23495
    UniProt: O14836

  • Chr Location
    17p11.2; chr17:16929816-16972118 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tnfrsf13b mouse models; 1 with human TNFRSF13B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show increased B cell numbers and splenomegaly. Homozygotes for a null allele show impaired T cell-independent immune responses and isotype switching. Homozygotes for another null allele develop lymphoproliferation and fatal autoimmune nephritis with high titers of autoantibodies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    630
  • Tissues
    22
  • cDNA Data
    40
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010142 Ensembl Gene Model | MGI Sequence Detail 22618 C57BL/6J ±  kb
    transcript ENSMUST00000010286 Ensembl | MGI Sequence Detail 2556 Not Applicable  
    polypeptide ENSMUSP00000010286 Ensembl | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 41
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1918966
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 8
      Phenotypes 54
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:376602 Doll JR, et al., BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth. Cell Rep. 2023 Apr 5;42(4):112352
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory