About   Help   FAQ
Cops6 Gene Detail
Summary
  • Symbol
    Cops6
  • Name
    COP9 signalosome subunit 6
  • Synonyms
    COP9 complex S6, Sgn3, VIP/MOV34
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349439
    NCBI Gene: 26893
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:138159364-138162246 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.97 cM, cytoband G1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349439
 protein coding gene Chr5:138159333-138162908 (+)
129S1/SvImJ ENSMUSG00200041906
 protein coding gene Chr5:131972164-131975739 (+)
A/J ENSMUSG00195046377
 protein coding gene Chr5:131446562-131450137 (+)
AKR/J ENSMUSG00220046241
 protein coding gene Chr5:130910113-130913688 (+)
BALB/cJ ENSMUSG00180038519
 protein coding gene Chr5:131543149-131546724 (+)
C3H/HeJ ENSMUSG00175040496
 protein coding gene Chr5:133470628-133474203 (+)
C57BL/6NJ ENSMUSG00215045962
 protein coding gene Chr5:131603011-131606586 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027903
 protein coding gene Chr5:130909623-130913108 (+)
CAST/EiJ ENSTCUG00005008866
 protein coding gene Chr5:130788659-130792257 (+)
CBA/J ENSMUSG00210023925
 protein coding gene Chr5:132288176-132291751 (+)
DBA/2J ENSMUSG00185052249
 protein coding gene Chr5:135303503-135307078 (+)
FVB/NJ ENSMUSG00205040874
 protein coding gene Chr5:131187249-131190824 (+)
JF1/MsJ ENSUMUG00000020444
 protein coding gene Chr5:138171402-138174956 (+)
LP/J ENSMUSG00230042442
 protein coding gene Chr5:139416967-139420542 (+)
NOD/ShiLtJ ENSMUSG00190043306
 protein coding gene Chr5:131242810-131246385 (+)
NZO/HlLtJ ENSMUSG00225023095
 protein coding gene Chr5:147088808-147092383 (+)
PWK/PhJ ENSLUMG00010014447
 protein coding gene Chr5:130044461-130048032 (+)
SPRET/EiJ ENSMSPG00010027412
 protein coding gene Chr5:133416139-133419766 (+)
WSB/EiJ ENSIUOG00005036960
 protein coding gene Chr5:133888792-133892366 (+)



Homology
more
  • Human Ortholog
    COPS6, COP9 signalosome subunit 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COPS6, COP9 signalosome subunit 6
  • Synonyms
    CSN6, MOV34-34KD
  • Links
    NCBI Gene ID: 10980
    UniProt: Q7L5N1

  • Chr Location
    7q22.1; chr7:100088948-100093340 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    4 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele or a transgenic gene disruption exhibit embryonic lethality. Mice heterozygous for a gene trap allele exhibit increased sensitivity to irradiation and decreased incidence of ionizing radiation-induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    668
  • Tissues
    65
  • cDNA Data
    143
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26893 NCBI Gene Model | MGI Sequence Detail 2883 C57BL/6J ±  kb
    transcript NM_012002 RefSeq | MGI Sequence Detail 1094 C57BL/6  
    polypeptide O88545 UniProt | EBI | MGI Sequence Detail 324 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 145
      cDNA 144
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
    • Latest
      J:381299 Liang E, et al., COP9 Signalosome Subunit 3 Restricts Neuroinflammatory Responses During Cerebral Ischemia/Reperfusion Injury Through Stabilizing Suppressor of Cytokine Signaling 3 Protein. Neuropsychiatr Dis Treat. 2021;17:1217-1227
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory