Cops6 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cops6
COP9 signalosome subunit 6
MGI:1349439

8 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cops6^{Gt(RRI087)Byg}/Cops6⁺ involves: 129P2/OlaHsd * C57BL/6J	decreased incidence of tumors by ionizing radiation induction	J:172038
	increased cellular sensitivity to gamma-irradiation	J:172038
	increased mortality induced by gamma-irradiation	J:172038
	increased sensitivity to induced cell death	J:172038
	increased thymocyte apoptosis	J:172038
Cops6^{Gt(RRI087)Byg}/Cops6^{Gt(RRI087)Byg} involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	embryonic lethality during organogenesis, complete penetrance	J:172038
Cops6^{Gt(RRI087)Byg}/Cops6^{Gt(RRI087)Byg} involves: 129P2/OlaHsd * C57BL/6J	embryonic lethality between somite formation and embryo turning, incomplete penetrance	J:172038
	embryonic lethality during organogenesis, complete penetrance	J:172038
Cops6^{Tg(Tyr)2261FOve}/Cops6^{Tg(Tyr)2261FOve} FVB/N-Cops6^{Tg(Tyr)2261FOve}	embryonic lethality between implantation and somite formation, complete penetrance	J:175597

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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