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Sh2d1b1 Gene Detail
Summary
  • Symbol
    Sh2d1b1
  • Name
    SH2 domain containing 1B1
  • Synonyms
    Eat2, EAT-2, Eat2a, Sh2d1b
Location &
Maps
more
  • Sequence Map
    Chr1:170104889-170114338 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 76.84 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    405 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349420
 protein coding gene Chr1:170104887-170114338 (+)
129S1/SvImJ ENSMUSG00200042899
 protein coding gene Chr1:167569019-167578455 (+)
A/J ENSMUSG00195045786
 protein coding gene Chr1:166888312-166897734 (+)
AKR/J ENSMUSG00220025636
 protein coding gene Chr1:166596550-166605999 (+)
BALB/cJ ENSMUSG00180043525
 protein coding gene Chr1:167164369-167173818 (+)
C3H/HeJ ENSMUSG00175046898
 protein coding gene Chr1:167224609-167234044 (+)
C57BL/6NJ ENSMUSG00215044499
 protein coding gene Chr1:167045659-167055108 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014839
 protein coding gene Chr1:160489641-160541499 (+)
CAST/EiJ ENSTCUG00005045325
 protein coding gene Chr1:165554533-165564001 (+)
CBA/J ENSMUSG00210038169
 protein coding gene Chr1:167129443-167138892 (+)
DBA/2J ENSMUSG00185011682
 protein coding gene Chr1:171346225-171355674 (+)
FVB/NJ ENSMUSG00205025112
 protein coding gene Chr1:166086758-166096194 (+)
JF1/MsJ ENSUMUG00000004625
 protein coding gene Chr1:170489524-170498975 (+)
LP/J ENSMUSG00230023400
 protein coding gene Chr1:170955773-170963841 (+)
NOD/ShiLtJ ENSMUSG00190027571
 protein coding gene Chr1:166887361-166896792 (+)
NZO/HlLtJ ENSMUSG00225003380
 protein coding gene Chr1:174561822-174571266 (+)
PWK/PhJ ENSLUMG00010027382
 protein coding gene Chr1:165880552-165889997 (+)
SPRET/EiJ ENSMSPG00010047192
 protein coding gene Chr1:169434030-169442062 (+)
WSB/EiJ ENSIUOG00005035156
 protein coding gene Chr1:166295828-166305264 (+)



Homology
more
  • Human Ortholog
    SH2D1B, SH2 domain containing 1B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH2D1B, SH2 domain containing 1B
  • Synonyms
    EAT2
  • Links
    NCBI Gene ID: 117157
    UniProt: O14796

  • Chr Location
    1q23.3; chr1:162395268-162412138 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 5 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit NK cells with enhanced cytolytic capacity and an increased IFN-gamma secretion. Mice homozygous for a different knock-out allele exhibit impaired NK cell cytolysis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000102418 Ensembl Gene Model | MGI Sequence Detail 9450 C57BL/6J ±  kb
transcript ENSMUST00000179976 Ensembl | MGI Sequence Detail 2544 Not Applicable  
polypeptide ENSMUSP00000137069 Ensembl | MGI Sequence Detail 132 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
References
more
  • Summaries
    All 47
    Gene Ontology 8
    Phenotypes 21
  • Earliest
    J:51754 Thompson AD, et al., EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene. Oncogene. 1996 Dec 19;13(12):2649-58
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory