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Apc2 Gene Detail
Summary
  • Symbol
    Apc2
  • Name
    APC regulator of WNT signaling pathway 2
  • Synonyms
    APCL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346052
    NCBI Gene: 23805
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80131811-80154097 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband B5-C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    432 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346052
 protein coding gene Chr10:80131790-80154097 (+)
129S1/SvImJ ENSMUSG00200049079
 protein coding gene Chr10:76755485-76777785 (+)
A/J ENSMUSG00195039773
 protein coding gene Chr10:77151039-77173333 (+)
AKR/J ENSMUSG00220046059
 protein coding gene Chr10:76748607-76770901 (+)
BALB/cJ ENSMUSG00180049258
 protein coding gene Chr10:77161543-77183831 (+)
C3H/HeJ ENSMUSG00175050381
 protein coding gene Chr10:77032220-77054519 (+)
C57BL/6NJ ENSMUSG00215048825
 protein coding gene Chr10:76773948-76796234 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015576
 protein coding gene Chr10:74283217-74305518 (+)
CAST/EiJ ENSTCUG00005051289
 protein coding gene Chr10:76658614-76681031 (+)
CBA/J ENSMUSG00210038200
 protein coding gene Chr10:76888301-76910600 (+)
DBA/2J ENSMUSG00185047522
 protein coding gene Chr10:77230677-77252969 (+)
FVB/NJ ENSMUSG00205047840
 protein coding gene Chr10:76943465-76965765 (+)
JF1/MsJ ENSUMUG00000055268
 protein coding gene Chr10:78459120-78481725 (+)
LP/J ENSMUSG00230044826
 protein coding gene Chr10:79000413-79022705 (+)
NOD/ShiLtJ ENSMUSG00190036447
 protein coding gene Chr10:77144404-77166699 (+)
NZO/HlLtJ ENSMUSG00225048254
 protein coding gene Chr10:83286765-83309055 (+)
PWK/PhJ ENSLUMG00010039672
 protein coding gene Chr10:76820807-76843371 (+)
SPRET/EiJ ENSMSPG00010044202
 protein coding gene Chr10:78442310-78464982 (+)
WSB/EiJ ENSIUOG00005043323
 protein coding gene Chr10:76848407-76870748 (+)



Homology
more
  • Human Ortholog
    APC2, APC regulator of Wnt signaling pathway 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APC2, APC regulator of Wnt signaling pathway 2
  • Synonyms
    APCL, MRT74
  • Links
    NCBI Gene ID: 10297
    UniProt: O95996

  • Chr Location
    19p13.3; chr19:1446230-1473244 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human APC2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    49
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    858
  • Tissues
    131
  • cDNA Data
    8
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020135 Ensembl Gene Model | MGI Sequence Detail 22287 C57BL/6J ±  kb
    transcript ENSMUST00000105359 Ensembl | MGI Sequence Detail 9173 Not Applicable  
    polypeptide ENSMUSP00000100996 Ensembl | MGI Sequence Detail 2303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000004123 adenomatous polyposis coli protein 2
      (term hierarchy)
    • InterPro Domains
      IPR026818 Adenomatous polyposis coli (APC) family
      IPR041257 Adenomatous polyposis coli (APC) repeat
      IPR032038 Adenomatous polyposis coli, N-terminal dimerisation domain
      IPR026831 Adenomatous polyposis coli protein
      IPR009234 Adenomatous polyposis coli protein basic domain
      IPR009223 Adenomatous polyposis coli protein repeat
      IPR036149 APC, N-terminal coiled-coil domain superfamily
      IPR000225 Armadillo
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR009224 SAMP
    • GlyGen
      Q9Z1K7 12 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 2
      cDNA 8
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143692, MGI:2143960
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:354447 Zhang Y, et al., Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2alpha phosphorylation via protein interactors and actin cytoskeleton. Hum Mol Genet. 2024 Sep 19;33(19):1671-1687
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory