Apc2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Apc2
APC regulator of WNT signaling pathway 2
MGI:1346052

20 phenotypes from 1 allele in 1 genetic background

Allelic Composition Genetic Background	Annotated Term	Reference
Apc2^tm1Mno/Apc2^tm1Mno involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal cerebellar granule cell migration	J:184856
	abnormal cerebellar layer morphology	J:184856
	abnormal dentate gyrus morphology	J:184856
	abnormal fertility/fecundity	J:184856
	abnormal hippocampus granule cell layer	J:184856
	abnormal hippocampus layer morphology	J:184856
	abnormal hippocampus pyramidal cell layer	J:184856
	abnormal neuronal migration	J:184856
	abnormal olfactory bulb layer morphology	J:184856
	abnormal olfactory bulb mitral cell layer morphology	J:184856
	abnormal stratification in cerebral cortex	J:184856
	ectopic cerebellar granule cells	J:184856
	ectopic hippocampus pyramidal cells	J:184856
	ectopic Purkinje cell	J:184856
	impaired coordination	J:184856
	increased neuron apoptosis	J:184856
	long stride length	J:184856
	loss of cortex neurons	J:184856
	postnatal growth retardation	J:184856
	seizures	J:184856

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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