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Coro1a Gene Detail
Summary
  • Symbol
    Coro1a
  • Name
    coronin, actin binding protein 1A
  • Synonyms
    Clabp, coronin 1, Lmb3, p57
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345961
    NCBI Gene: 12721
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126298946-126303925 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.25 cM, cytoband F3
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345961
 protein coding gene Chr7:126298945-126306959 (-)
129S1/SvImJ ENSMUSG00200023300
 protein coding gene Chr7:112803936-112811950 (-)
A/J ENSMUSG00195037660
 protein coding gene Chr7:117326105-117334109 (-)
AKR/J ENSMUSG00220018782
 protein coding gene Chr7:110753360-110761371 (-)
BALB/cJ ENSMUSG00180013309
 protein coding gene Chr7:113994018-114002028 (-)
C3H/HeJ ENSMUSG00175015406
 protein coding gene Chr7:114726996-114735010 (-)
C57BL/6NJ ENSMUSG00215025820
 protein coding gene Chr7:114006940-114014956 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030460
 protein coding gene Chr7:128715247-128723322 (-)
CAST/EiJ ENSTCUG00005048152
 protein coding gene Chr7:117221169-117229157 (-)
CBA/J ENSMUSG00210022590
 protein coding gene Chr7:114488080-114496094 (-)
DBA/2J ENSMUSG00185046791
 protein coding gene Chr7:118800926-118808940 (-)
FVB/NJ ENSMUSG00205039943
 protein coding gene Chr7:114440115-114448129 (-)
JF1/MsJ ENSUMUG00000030991
 protein coding gene Chr7:123854507-123862496 (-)
LP/J ENSMUSG00230053109
 protein coding gene Chr7:124903923-124911937 (-)
NOD/ShiLtJ ENSMUSG00190018339
 protein coding gene Chr7:114647105-114655113 (-)
NZO/HlLtJ ENSMUSG00225012315
 protein coding gene Chr7:123140044-123148048 (-)
PWK/PhJ ENSLUMG00010041419
 protein coding gene Chr7:112994398-113002412 (-)
SPRET/EiJ ENSMSPG00010012129
 protein coding gene Chr7:114264550-114272553 (-)
WSB/EiJ ENSIUOG00005027086
 protein coding gene Chr7:115349268-115357307 (-)



Homology
more
  • Human Ortholog
    CORO1A, coronin 1A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CORO1A, coronin 1A
  • Synonyms
    CLABP, CLIPINA, HCORO1, IMD8, p57, TACO
  • Links
    NCBI Gene ID: 11151
    UniProt: P31146

  • Chr Location
    16p11.2; chr16:30182817-30189085 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Coro1a mouse models; 1 with human CORO1A associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 7 alleles in 11 genetic backgrounds
    5 phenotypes from multigenic genotypes
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null or hypomorph alleles of this gene display lower peripheral T cell counts resulting from defects in T cell migration and increased rates of apoptosis. Adult mice homozygous for a knock-out allele show no significant brain neuroanatomical phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    94
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    60
  • cDNA Data
    126
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12721 NCBI Gene Model | MGI Sequence Detail 4980 C57BL/6J ±  kb
    transcript NM_001412248 RefSeq | MGI Sequence Detail 1734 ZRU/MplStud  
    polypeptide O89053 UniProt | EBI | MGI Sequence Detail 461 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      Genomic 1
      cDNA 127
      Primer pair 2
      Other 4
      Antibodies 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1203736, MGI:1278331
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 10
      Diseases 4
      Gene Ontology 14
      Phenotypes 91
    • Earliest
      J:141679 Yagi H, et al., Immune deficiency of cataract Shionogi (CTS) mouse. II. Impaired in vivo T cell-mediated immune response. Immunol Invest. 1990 Oct-Dec;19(5-6):493-505
    • Latest
      J:389705 Hao L, et al., Heart rate and sleep history encode ultradian REM sleep timing. Curr Biol. 2026 Mar 23;36(6):1422-1434.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/15/2026
    MGI 6.29     		The Jackson Laboratory