Phenotypes Associated with This Genotype

Genotype
MGI:3818533

• Allelic Composition: Coro1a^tm1Achn/Coro1a^tm1Achn
• Genetic Background: B6.129X1-Coro1a^tm1Achn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:141431 )

decreased thymocyte number ( J:141431 )

• the percentage of mature (CD69^loCD62L^hi) single-positive thymocytes is decreased in these mice

hematopoietic system

increased T cell apoptosis ( J:141431 )

decreased thymocyte number ( J:141431 )

• the percentage of mature (CD69^loCD62L^hi) single-positive thymocytes is decreased in these mice

cellular

increased T cell apoptosis ( J:141431 )

endocrine/exocrine glands

decreased thymocyte number ( J:141431 )

• the percentage of mature (CD69^loCD62L^hi) single-positive thymocytes is decreased in these mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive		DOID:0090014	OMIM:608971	J:141431