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Creg1 Gene Detail
Summary
  • Symbol
    Creg1
  • Name
    cellular repressor of E1A-stimulated genes 1
  • Synonyms
    Creg
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344382
    NCBI Gene: 433375
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:165591327-165602878 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 73.11 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    501 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344382
 protein coding gene Chr1:165591315-165602878 (+)
129S1/SvImJ ENSMUSG00200045510
 protein coding gene Chr1:163092143-163103676 (+)
A/J ENSMUSG00195046673
 protein coding gene Chr1:162400741-162412279 (+)
AKR/J ENSMUSG00220013447
 protein coding gene Chr1:162189277-162200812 (+)
BALB/cJ ENSMUSG00180031773
 protein coding gene Chr1:162646154-162657689 (+)
C3H/HeJ ENSMUSG00175039830
 protein coding gene Chr1:162741894-162753429 (+)
C57BL/6NJ ENSMUSG00215039385
 protein coding gene Chr1:162527805-162539340 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014809
 protein coding gene Chr1:156170825-156182146 (+)
CAST/EiJ ENSTCUG00005018701
 protein coding gene Chr1:161161130-161173174 (+)
CBA/J ENSMUSG00210020421
 protein coding gene Chr1:162616371-162627906 (+)
DBA/2J ENSMUSG00185011024
 protein coding gene Chr1:166863416-166874063 (+)
FVB/NJ ENSMUSG00205009038
 protein coding gene Chr1:161655385-161666913 (+)
JF1/MsJ ENSUMUG00000004206
 protein coding gene Chr1:166014523-166026554 (+)
LP/J ENSMUSG00230022920
 protein coding gene Chr1:166481226-166492761 (+)
NOD/ShiLtJ ENSMUSG00190024877
 protein coding gene Chr1:162448096-162459594 (+)
NZO/HlLtJ ENSMUSG00225004249
 protein coding gene Chr1:170067024-170078559 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010047762
 protein coding gene Chr1:164882004-164893817 (+)
WSB/EiJ ENSIUOG00005013621
 protein coding gene Chr1:161929469-161941020 (+)



Homology
more
  • Human Ortholog
    CREG1, cellular repressor of E1A stimulated genes 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CREG1, cellular repressor of E1A stimulated genes 1
  • Synonyms
    CREG
  • Links
    NCBI Gene ID: 8804
    UniProt: O75629

  • Chr Location
    1q24.2; chr1:167529117-167553822 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 3 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit decreased neovascularization after induction of hindlimb ischemia, and show increased infarction size, elevated cardiomyocyte apoptosis and impaired autophagy following myocardial ischemia/reperfusion injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    666
  • Tissues
    46
  • cDNA Data
    11
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 433375 NCBI Gene Model | MGI Sequence Detail 11552 C57BL/6J ±  kb
    transcript NR_149310 RefSeq | MGI Sequence Detail 2323 C57BL/6  
    polypeptide O88668 UniProt | EBI | MGI Sequence Detail 220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138129
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:53002 Veal E, et al., A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. Mol Cell Biol. 1998 Sep;18(9):5032-41
    • Latest
      J:344665 Liu D, et al., The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes. Exp Mol Med. 2023 Sep;55(9):2025-2038
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory