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Cflar Gene Detail
Summary
  • Symbol
    Cflar
  • Name
    CASP8 and FADD-like apoptosis regulator
  • Synonyms
    2310024N18Rik, A430105C05Rik, Cash, Casper, c-Flip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336166
    NCBI Gene: 12633
  • Alliance
  • Transcription Start Sites
    48 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:58750667-58798043 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 29.16 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1184 from dbSNP Build 142
  • Strain Annotations
    40
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336166
protein coding gene Chr1:58750353-58798043 (+)
129S1/SvImJ ENSMUSG00200005356
protein coding gene Chr3:36152548-36154366 (-)
129S1/SvImJ ENSMUSG00200018508
protein coding gene Chr1:56195133-56343722 (+)
A/J ENSMUSG00195026118
protein coding gene Chr1:55788418-55799064 (+)
A/J ENSMUSG00195026040
protein coding gene Chr1:55728364-55877065 (+)
A/J ENSMUSG00195001401
protein coding gene Chr3:36121646-36123464 (-)
AKR/J ENSMUSG00220000575
protein coding gene Chr3:36221694-36223512 (-)
AKR/J ENSMUSG00220038735
protein coding gene Chr1:55877505-55889241 (+)
AKR/J ENSMUSG00220038625
protein coding gene Chr1:55879738-55967257 (+)
BALB/cJ ENSMUSG00180013985
protein coding gene Chr1:56040618-56052342 (+)
BALB/cJ ENSMUSG00180013967
protein coding gene Chr1:56055588-56130330 (+)
BALB/cJ ENSMUSG00180002641
protein coding gene Chr3:36275947-36277765 (-)
C3H/HeJ ENSMUSG00175003254
protein coding gene Chr3:36150884-36152702 (-)
C3H/HeJ ENSMUSG00175000924
protein coding gene Chr1:56105864-56254571 (+)
C3H/HeJ ENSMUSG00175000927
protein coding gene Chr1:56165912-56176555 (+)
C57BL/6NJ ENSMUSG00215023642
protein coding gene Chr1:56037651-56186360 (+)
C57BL/6NJ ENSMUSG00215001334
protein coding gene Chr3:36547837-36549655 (-)
C57BL/6NJ ENSMUSG00215024233
protein coding gene Chr1:56097709-56108353 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014169
protein coding gene Chr1:52463656-52503455 (+)
CAST/EiJ ENSTCUG00005012470
protein coding gene Chr1:55880564-56023917 (+)
CBA/J ENSMUSG00210031521
protein coding gene Chr1:55849921-55897304 (+)
CBA/J ENSMUSG00210000998
protein coding gene Chr3:36212213-36214031 (-)
CBA/J ENSMUSG00210031738
protein coding gene Chr1:55850803-55861439 (+)
DBA/2J ENSMUSG00185054471
protein coding gene Chr1:56970493-56981130 (+)
DBA/2J ENSMUSG00185054408
protein coding gene Chr1:56910860-57059083 (+)
DBA/2J ENSMUSG00185000999
protein coding gene Chr3:36426685-36428503 (-)
FVB/NJ ENSMUSG00205017386
protein coding gene Chr1:55812875-55858263 (+)
FVB/NJ ENSMUSG00205017591
protein coding gene Chr1:55810640-55825611 (+)
JF1/MsJ ENSUMUG00000035402
protein coding gene Chr1:55931114-55976207 (+)
LP/J ENSMUSG00230024512
protein coding gene Chr1:56975750-56986389 (+)
LP/J ENSMUSG00230024467
protein coding gene Chr1:56915690-57064343 (+)
LP/J ENSMUSG00230019243
protein coding gene Chr3:38393550-38395368 (-)
NOD/ShiLtJ ENSMUSG00190032615
protein coding gene Chr1:55957378-56111459 (+)
NOD/ShiLtJ ENSMUSG00190001415
protein coding gene Chr3:36485666-36487484 (-)
NZO/HlLtJ ENSMUSG00225007586
protein coding gene Chr1:60119185-60266761 (+)
NZO/HlLtJ ENSMUSG00225007607
protein coding gene Chr1:60178118-60188756 (+)
NZO/HlLtJ ENSMUSG00225000397
protein coding gene Chr3:41014461-41016279 (-)
PWK/PhJ ENSLUMG00010023704
protein coding gene Chr1:55462742-55508139 (+)
SPRET/EiJ ENSMSPG00010022591
protein coding gene Chr1:57388941-57434464 (+)
WSB/EiJ ENSIUOG00005020034
protein coding gene Chr1:55582804-55694400 (+)



Homology
more
  • Human Ortholog
    CFLAR, CASP8 and FADD like apoptosis regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CFLAR, CASP8 and FADD like apoptosis regulator
  • Synonyms
    CASH, CASP8AP1, Casper, c-FLIP, cFLIP, c-FLIPL, c-FLIPR, c-FLIPS, CLARP, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT
  • Links
    NCBI Gene ID: 8837
    UniProt: O15519

  • Chr Location
    2q33.1; chr2:201116154-201176687 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 5 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality by E10.5. Mutant embryos exhibit cardiac developmental abnormalities and pooling of blood in the head and abdominal regions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026031 Ensembl Gene Model | MGI Sequence Detail 47377 C57BL/6J ±  kb
    transcript ENSMUST00000097722 Ensembl | MGI Sequence Detail 1771 Not Applicable  
    polypeptide ENSMUSP00000095329 Ensembl | MGI Sequence Detail 484 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 22
      Antibodies 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1096876, MGI:1916820, MGI:1925024, MGI:2138307, MGI:2138466
    References
    more
    • Summaries
      All 179
      Developmental Gene Expression 16
      Gene Ontology 14
      Phenotypes 53
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:377029 Newton K: Wickliffe KE, et al., cFLIP suppresses caspase-1- and MLKL-independent perinatal lethality driven by auto-processing impaired caspase-8 D387A. Cell Death Differ. 2025;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/15/2026
    MGI 6.29
    The Jackson Laboratory